Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 13/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 13/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 13/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL332825 | 0.89 | ALOX5 (0.49) | ALOX5PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL332537 | 0.71 | ALOX5 (0.74) | ALOX5PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL332725 | 0.71 | ALOX5 (0.53) | ALOX5PIK3CD | |
| SCHEMBL332555 | 0.66 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3655644 | 0.66 | ALOX5 (0.42) | ALOX5LRRK2 | |
| SCHEMBL3660567 | 0.65 | ALOX5 (0.46) | ALOX5PIK3CD | |
| SCHEMBL333095 | 0.65 | ALOX5 (0.63) | ALOX5PIK3CD | |
| SCHEMBL20028646 | 0.64 | ALDH1A1 (0.47) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7586503 | 0.64 | PDE4B (0.44) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL20028645 | 0.63 | PDE4B (0.48) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225229-A1 | PYRAZOLE DERIVATIVES AS 5-LO INHIBITORS | Pfizer Inc. (US) | 2010-09-08 | — | — | EP | disclosed |
| WO-2009069044-A1 | PYRAZOLE DERIVATIVES AS 5-LO INHIBITORS | PFIZER INC. (US) | 2009-06-04 | — | — | WO | disclosed |