Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | AR | P10275 | 1/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.50 |
| ▸ | AXL | P30530 | 1/20 | 0.50 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.50 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.50 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.50 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.49 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.49 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9957782 | 0.93 | KDM4E (0.62) | KDM4EKMT2AARCYP19A1AXL | |
| SCHEMBL6217477 | 0.84 | ALDH1A1 (0.62) | KDM4EKMT2AARMKNK1MKNK2 | |
| SCHEMBL61174 | 0.82 | RECQL (0.53) | KDM4ESREBF2RAB9AALDH1A1NPC1 | |
| SCHEMBL3141486 | 0.80 | CYP3A4 (0.56) | KDM4EKMT2AARCYP19A1SREBF2 | |
| SCHEMBL28806539 | 0.80 | CYP19A1 (0.36) | KDM4EKMT2AARCYP19A1AXL | |
| SCHEMBL694619 | 0.76 | KDM4E (0.69) | KDM4EKMT2AARCYP19A1SREBF2 | |
| SCHEMBL714474 | 0.76 | KDM4E (0.69) | KDM4EKMT2AARCYP19A1SREBF2 | |
| SCHEMBL17626149 | 0.76 | RAB9A (0.45) | KDM4ESREBF2RAB9AALDH1A1NPC1 | |
| SCHEMBL2781370 | 0.74 | KDM4E (0.85) | KDM4EKMT2AARCYP19A1SREBF2 | |
| SCHEMBL11213828 | 0.72 | SREBF2 (0.82) | KDM4EKMT2AARCYP19A1SREBF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2190421-A2 | 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS FOR THE TREATMENT OF HORMONE-DEPENDENT DISEASES | Universität des Saarlandes (DE) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009027346-A2 | 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS FOR THE TREATMENT OF HORMONE-DEPENDENT DISEASES | Universität des Saarlandes (DE) | 2009-03-05 | — | — | WO | disclosed |