Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP7 | Q93009 | 2/20 | 0.48 |
| ▸ | CCNC | P24863 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | CHUK | O15111 | 1/20 | 0.35 |
| ▸ | GYS1 | P13807 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 2/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27864411 | 0.80 | BCAT2 (0.46) | USP7CCNCCDK8HSD17B10KIF11 | |
| SCHEMBL2114819 | 0.77 | HSD17B10 (0.46) | USP7HSD17B10MMP2MMP3BCAT2 | |
| SCHEMBL4964937 | 0.75 | KIF11 (0.44) | USP7KIF11PDK2ESR1ESR2 | |
| SCHEMBL7064896 | 0.74 | ESR1 (0.43) | HSD17B10MMP2MMP3CHUKESR1 | |
| SCHEMBL27724987 | 0.74 | KIF11 (0.50) | HSD17B10KIF11CYP2C8ESR1ESR2 | |
| SCHEMBL2114962 | 0.72 | BCAT2 (0.52) | USP7HSD17B10MMP2MMP3PDK2 | |
| SCHEMBL28013764 | 0.71 | IKBKB (0.49) | HSD17B10IKBKBCHUKBCAT2BTK | |
| SCHEMBL15779321 | 0.70 | HSD17B10 (0.53) | USP7HSD17B10MMP2MMP3BCAT2 | |
| SCHEMBL4750554 | 0.69 | DGAT1 (0.41) | HSD17B10MMP2MMP3ESR1ESR2 | |
| SCHEMBL21629968 | 0.68 | BCAT2 (0.46) | HSD17B10IKBKBCHUKPDK2BCAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954670-A2 | NUCLEAR RECEPTOR BINDING AGENTS | GTX Inc. (US) | 2008-08-13 | — | — | EP | claimed |
| WO-2007062230-A2 | NUCLEAR RECEPTOR BINDING AGENTS | GTX, INC. (US) | 2007-05-31 | — | — | WO | claimed |
| CN-102413692-B | Estrogen receptor ligands and methods of use thereof | GTX INC | 2015-01-07 | — | — | CN | disclosed |
| WO-2010096801-A1 | ESTROGEN RECEPTOR LIGANDS AND METHODS OF USE THEREOF | GTX, INC. (US) | 2010-08-26 | — | — | WO | disclosed |