Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 9/20 | 0.35 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.34 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 4/20 | 0.34 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL381380 | 0.90 | TP53 (0.39) | ATMDPP4DPP8DPP7DPP9 | |
| Trifluoroacetic Acid SCHEMBL381863 | 0.89 | AKR1C2 (0.41) | FFAR4 | |
| Trifluoroacetic Acid SCHEMBL381532 | 0.89 | PRCP (0.38) | DPP4DPP8DPP7DPP9HTR2A | |
| Trifluoroacetic Acid SCHEMBL381484 | 0.87 | P2RY14 (0.37) | DPP4DPP8DPP7 | |
| Trifluoroacetic Acid SCHEMBL381517 | 0.85 | PAX8 (0.35) | DPP4DPP8DPP7DPP9 | |
| SCHEMBL3563833 | 0.83 | AKR1C2 (0.38) | HTR2A | |
| SCHEMBL3563830 | 0.83 | AKR1C2 (0.38) | HTR2A | |
| SCHEMBL381598 | 0.82 | TP53 (0.43) | DPP4 | |
| SCHEMBL381599 | 0.82 | TP53 (0.43) | DPP4 | |
| SCHEMBL13031220 | 0.82 | HTR2A (0.35) | FFAR4PTGDRHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049513-B1 | PIPERIDINYL SUBSTITUTED PYRROLIDINONES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | LILLY CO ELI (US) | 2012-01-25 | — | — | EP | disclosed |
| US-7829582-B2 | Piperidinyl substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 | ELI LILLY AND COMPANY (US) | 2010-11-09 | — | — | US | disclosed |