Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY14 | Q15391 | 9/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | DRD5 | P21918 | 4/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.35 |
| ▸ | DRD1 | P21728 | 3/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL381532 | 0.93 | PRCP (0.38) | DPP4DPP8DPP7HSD11B1CHRM2 | |
| Trifluoroacetic Acid SCHEMBL381380 | 0.92 | TP53 (0.39) | P2RY14DPP4DPP8DPP7HSD11B1 | |
| Trifluoroacetic Acid SCHEMBL380865 | 0.90 | S1PR5 (0.38) | HSD11B1MCHR1P2RX7PLAT | |
| Trifluoroacetic Acid SCHEMBL381863 | 0.89 | AKR1C2 (0.41) | P2RY14HSD11B1DRD3PTGS2CHRM2 | |
| Trifluoroacetic Acid SCHEMBL381517 | 0.89 | PAX8 (0.35) | P2RY14DPP4DPP8DPP7HSD11B1 | |
| Trifluoroacetic Acid SCHEMBL380699 | 0.87 | FFAR4 (0.35) | DPP4DPP8DPP7 | |
| Trifluoroacetic Acid SCHEMBL381171 | 0.85 | P2RX7 (0.40) | DPP4DPP7HSD11B1SLC6A2SLC6A4 | |
| Trifluoroacetic Acid SCHEMBL380667 | 0.85 | RAD52 (0.39) | ADRA2CSLC6A2SLC6A3SLC6A4CHRM2 | |
| Trifluoroacetic Acid SCHEMBL381002 | 0.85 | L3MBTL1 (0.39) | HSD11B1F10KCNH2 | |
| SCHEMBL3564422 | 0.84 | HTR2A (0.43) | HSD11B1HTR1ACHRM2HTR7FPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049513-B1 | PIPERIDINYL SUBSTITUTED PYRROLIDINONES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | LILLY CO ELI (US) | 2012-01-25 | — | — | EP | disclosed |
| US-7829582-B2 | Piperidinyl substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 | ELI LILLY AND COMPANY (US) | 2010-11-09 | — | — | US | disclosed |