Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.63 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.63 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | CA1 | P00915 | 1/20 | 0.60 |
| ▸ | CA2 | P00918 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1852796 | 0.94 | SMN1; SMN2 (0.74) | SMN1; SMN2KMT2ASLC6A2SLC6A3TDP1 | |
| SCHEMBL22388846 | 0.91 | KMT2A (0.76) | SMN1; SMN2KMT2ASLC6A2SLC6A3TDP1 | |
| SCHEMBL3746846 | 0.91 | SMN1; SMN2 (0.73) | SMN1; SMN2KMT2ALMNAHPGDNPC1 | |
| Hydrochloric Acid SCHEMBL1169317 | 0.89 | SMN1; SMN2 (0.71) | SMN1; SMN2KMT2ALMNAHPGDNPC1 | |
| SCHEMBL6647657 | 0.84 | PKM (0.61) | SMN1; SMN2KMT2ASLC6A2SLC6A3TDP1 | |
| SCHEMBL4766309 | 0.84 | SMN1; SMN2 (0.62) | SMN1; SMN2KMT2ASLC6A2SLC6A3TDP1 | |
| SCHEMBL2478030 | 0.84 | KMT2A (0.61) | SMN1; SMN2KMT2ASLC6A2SLC6A3TDP1 | |
| SCHEMBL9016956 | 0.84 | LMNA (0.68) | SMN1; SMN2KMT2ATDP1LMNAALDH1A1 | |
| SCHEMBL1855497 | 0.83 | SMN1; SMN2 (0.60) | SMN1; SMN2KMT2ASLC6A2SLC6A3TDP1 | |
| SCHEMBL10740603 | 0.83 | SMN1; SMN2 (0.60) | SMN1; SMN2KMT2ASLC6A2SLC6A3TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476253-B2 | Amide derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-07-02 | — | — | US | disclosed |
| US-20120071467-A1 | AMIDE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-03-22 | — | — | US | disclosed |
| EP-2409977-A1 | AMIDE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2012-01-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071467-A1 | AMIDE DERIVATIVE | CHRM3, CHRM2, TACR2 | SMN1; SMN2 1907/4885KMT2A 211/4885SLC6A2 1071/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.