Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | CLK3 | P49761 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | JUN | P05412 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3712135 | 0.81 | CLK2 (0.42) | CLK2CLK3DYRK1ACHRNB2CHRNA4 | |
| SCHEMBL3712134 | 0.81 | CLK2 (0.42) | CLK2CLK3DYRK1ACHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL3732874 | 0.80 | CLK2 (0.42) | CLK2CLK3DYRK1ACHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL3732878 | 0.80 | CLK2 (0.42) | CLK2CLK3DYRK1ACHRNB2CHRNA4 | |
| SCHEMBL1631738 | 0.64 | CHRNB2 (0.47) | CHRNB2CHRNA4CYP11B1CYP11B2CHRNB4 | |
| SCHEMBL29691639 | 0.63 | CYP11B1 (0.86) | CHRNB2CHRNA4CYP11B1CYP11B2CHRNB4 | |
| SCHEMBL29691623 | 0.63 | CYP11B1 (0.86) | CHRNB2CHRNA4CYP11B1CYP11B2CHRNB4 | |
| SCHEMBL3801386 | 0.63 | PDE10A (0.35) | ALDH1A1KDM4E | |
| SCHEMBL11470273 | 0.63 | RAB9A (0.62) | NPC1RAB9AKDM4EJUNMAPT | |
| SCHEMBL11470275 | 0.63 | RAB9A (0.62) | NPC1RAB9AKDM4EJUNMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2242757-A1 | PYRAZOLOPYRIDINES AS KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2010-10-27 | — | — | EP | disclosed |
| WO-2009089359-A1 | PYRAZOLOPYRIDINES AS KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2009-07-16 | — | — | WO | disclosed |