Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | ACACA | Q13085 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL146557 | 0.85 | THRB (0.45) | THRBTSHRPOLBAPEX1HTT | |
| SCHEMBL11921516 | 0.83 | THRB (0.55) | THRBTSHRPOLBAPEX1HTT | |
| SCHEMBL22566492 | 0.82 | THRB (0.53) | THRBTSHRPOLBAPEX1HTT | |
| SCHEMBL26092718 | 0.79 | THRB (0.47) | THRBTSHRPOLBAPEX1HTT | |
| SCHEMBL10457799 | 0.79 | THRB (0.50) | THRBTSHRPOLBAPEX1HTT | |
| SCHEMBL1119186 | 0.77 | NPC1 (0.51) | THRBTSHRPOLBAPEX1HTT | |
| SCHEMBL13221752 | 0.77 | THRB (0.49) | THRBTSHRPOLBAPEX1HTT | |
| SCHEMBL147451 | 0.77 | THRB (0.53) | THRBTSHRPOLBAPEX1HTT | |
| SCHEMBL296203 | 0.77 | CA1 (0.49) | THRBTSHRPOLBAPEX1HTT | |
| SCHEMBL21083151 | 0.77 | THRB (0.42) | THRBTSHRPOLBAPEX1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2032102-A2 | OPTICAL MATERIAL AND METHOD FOR MODIFYING THE REFRACTIVE INDEX | Bausch & Lomb Incorporated (US) | 2009-03-11 | — | — | EP | disclosed |
| WO-2008002796-A2 | OPTICAL MATERIAL AND METHOD FOR MODIFYING THE REFRACTIVE INDEX | BAUSCH & LOMB INCORPORATED (US) | 2008-01-03 | — | — | WO | disclosed |