Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | PNP | P00491 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | WNT3A | P56704 | 1/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL46453 | 0.85 | KDM4E (0.50) | PDE5AKDM4ESMN1; SMN2LMNATSHR | |
| SCHEMBL37513 | 0.83 | PDE5A (0.79) | PDE5AKDM4ETSHRPKMGAA | |
| SCHEMBL3491443 | 0.81 | PDE5A (0.63) | PDE5AKDM4ESMN1; SMN2LMNATSHR | |
| SCHEMBL37536 | 0.81 | PDE5A (0.60) | PDE5AKDM4ESMN1; SMN2LMNAPOLB | |
| SCHEMBL37981 | 0.79 | PDE5A (0.66) | PDE5AKDM4ESMN1; SMN2LMNAPNP | |
| SCHEMBL38005 | 0.79 | PDE5A (0.69) | PDE5AKDM4E | |
| SCHEMBL37737 | 0.78 | PDE5A (0.68) | PDE5AKDM4ESMN1; SMN2LMNAPOLB | |
| SCHEMBL37583 | 0.78 | PDE5A (0.78) | PDE5AKDM4E | |
| SCHEMBL12505649 | 0.78 | PDE5A (0.65) | PDE5AKDM4ESMN1; SMN2LMNARAB9A | |
| SCHEMBL38235 | 0.78 | PDE5A (0.62) | PDE5AKDM4ELMNAPOLBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012004900-A1 | THIENOPYRIMIDINE COMPOUNDS | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2012-01-12 | — | — | WO | disclosed |
| WO-2012004900-A1 | THIENOPYRIMIDINE COMPOUNDS | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2012-01-12 | — | — | WO | disclosed |