Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 3/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | RNASEH1 | O60930 | 2/20 | 0.53 |
| ▸ | CDC7 | O00311 | 2/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.47 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38005 | 0.90 | PDE5A (0.69) | PDE5AKMT2ARNASEH1CDC7CCNE1 | |
| SCHEMBL37583 | 0.89 | PDE5A (0.78) | PDE5AKMT2ARNASEH1CDC7CCNE1 | |
| SCHEMBL44227 | 0.89 | PDE5A (0.67) | PDE5AKMT2ARNASEH1CDC7CCNE1 | |
| SCHEMBL37942 | 0.89 | PDE5A (0.78) | PDE5AKMT2ARNASEH1KDM4E | |
| SCHEMBL38065 | 0.88 | PDE5A (0.77) | PDE5AKMT2ARNASEH1CDC7CCNE1 | |
| SCHEMBL38178 | 0.88 | PDE5A (0.77) | PDE5AKMT2ARNASEH1CDC7CCNE1 | |
| SCHEMBL37798 | 0.88 | PDE5A (1.00) | PDE5AKMT2ARNASEH1CDC7CCNE1 | |
| SCHEMBL38373 | 0.86 | PDE5A (0.61) | PDE5AKMT2ARNASEH1CDC7CCNE1 | |
| SCHEMBL37797 | 0.85 | PDE5A (0.72) | PDE5AKMT2ACDC7CCNE1CDK2 | |
| SCHEMBL37981 | 0.85 | PDE5A (0.66) | PDE5AKMT2ARNASEH1CDC7CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012004900-A1 | THIENOPYRIMIDINE COMPOUNDS | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2012-01-12 | — | — | WO | disclosed |
| WO-2012004900-A1 | THIENOPYRIMIDINE COMPOUNDS | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2012-01-12 | — | — | WO | disclosed |