Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | PDE5A | O76074 | 1/20 | 0.49 |
| ▸ | CDC7 | O00311 | 3/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.44 |
| ▸ | CDK2 | P24941 | 3/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.44 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PNP | P00491 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38373 | 0.85 | PDE5A (0.61) | KDM4ESMN1; SMN2PDE5ACDC7CCNE1 | |
| SCHEMBL38116 | 0.85 | PDE5A (0.63) | KDM4ESMN1; SMN2PDE5ATSHRLMNA | |
| SCHEMBL4530199 | 0.84 | SMN1; SMN2 (0.50) | KDM4ESMN1; SMN2PDE5ATSHRLMNA | |
| SCHEMBL46291 | 0.82 | PDE5A (0.50) | PDE5ACDC7CCNE1CDK2ROCK1 | |
| SCHEMBL10084040 | 0.81 | PDE5A (0.59) | KDM4ESMN1; SMN2PDE5ACDC7CCNE1 | |
| SCHEMBL46289 | 0.81 | PDE5A (0.76) | KDM4ESMN1; SMN2PDE5ACDC7CCNE1 | |
| SCHEMBL10083509 | 0.81 | PDE5A (0.58) | PDE5ACDC7CCNE1CDK2ROCK1 | |
| SCHEMBL38484 | 0.80 | PDE5A (0.57) | KDM4ESMN1; SMN2PDE5ACDC7CCNE1 | |
| SCHEMBL46296 | 0.77 | PDE5A (0.56) | KDM4ESMN1; SMN2PDE5ACDC7CCNE1 | |
| SCHEMBL4523121 | 0.76 | KMT2A (0.64) | KDM4ETSHRLMNAALDH1A1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012004900-A1 | THIENOPYRIMIDINE COMPOUNDS | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2012-01-12 | — | — | WO | disclosed |