Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 5/20 | 0.34 |
| ▸ | F11 | P03951 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.31 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.30 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13719700 | 0.90 | GRM5 (0.34) | GRM5KLKB1F11ALDH1A1STAT3 | |
| SCHEMBL3820036 | 0.90 | KLKB1 (0.38) | GRM5KLKB1F11ALDH1A1STAT3 | |
| SCHEMBL3812597 | 0.89 | KLKB1 (0.41) | GRM5KLKB1F11ALDH1A1STAT3 | |
| SCHEMBL1010952 | 0.87 | GRM5 (0.50) | GRM5ALDH1A1ESR1POLBESR2 | |
| SCHEMBL13719914 | 0.87 | ALDH1A1 (0.37) | GRM5ALDH1A1ESR1POLBESR2 | |
| SCHEMBL3821030 | 0.87 | GRM5 (0.38) | GRM5ALDH1A1ESR1POLBESR2 | |
| SCHEMBL3815259 | 0.86 | ALDH1A1 (0.37) | GRM5KLKB1F11ALDH1A1ESR1 | |
| SCHEMBL3820066 | 0.86 | ALDH1A1 (0.36) | GRM5KLKB1F11ALDH1A1ESR1 | |
| SCHEMBL3811951 | 0.85 | ADRA2A (0.35) | GRM5KLKB1F11P2RX7 | |
| SCHEMBL3818159 | 0.85 | DRD2 (0.35) | GRM5KLKB1F11ALDH1A1TRPC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | claimed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |