Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3809686 | 1.00 | MEN1 (0.34) | MEN1KMT2AMAOAMAOBMEP1B | |
| SCHEMBL909752 | 0.93 | KMT2A (0.38) | MEN1KMT2AMEP1BLMNACA2 | |
| SCHEMBL537494 | 0.93 | KMT2A (0.38) | MEN1KMT2AMEP1BLMNACA2 | |
| SCHEMBL909187 | 0.93 | KMT2A (0.38) | MEN1KMT2AMEP1BLMNACA2 | |
| SCHEMBL5153705 | 0.85 | ALDH1A1 (0.33) | MEN1KMT2AMEP1BLMNACA2 | |
| SCHEMBL30321034 | 0.83 | PRMT5 (0.42) | MEN1KMT2ALMNAMAPK1ALDH1A1 | |
| SCHEMBL20184269 | 0.83 | ALDH1A1 (0.44) | MEN1KMT2ALMNAKDM4EMAPK1 | |
| SCHEMBL27206070 | 0.82 | KDM4E (0.39) | KMT2AMEP1BLMNAKDM4EMAPK1 | |
| SCHEMBL32681961 | 0.81 | SLC6A2 (0.37) | MEN1KMT2AMEP1BLMNAKDM4E | |
| SCHEMBL4795645 | 0.79 | CA2 (0.39) | MEN1KMT2ALMNACA2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185537-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | Pfizer Inc. (US) | 2010-05-19 | — | — | EP | disclosed |
| WO-2009016498-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | PFIZER INC. (US) | 2009-02-05 | — | — | WO | disclosed |