Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 2/20 | 0.37 |
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.37 |
| ▸ | GRM5 | P41594 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3819764 | 0.89 | MAPK1 (0.34) | GRM5TP53ALDH1A1LMNATSHR | |
| SCHEMBL1009694 | 0.86 | ALDH1A1 (0.49) | GRM5GAAALDH1A1TSHRMAPT | |
| SCHEMBL3817104 | 0.84 | ALDH1A1 (0.36) | GRM5GAAALDH1A1LMNATSHR | |
| SCHEMBL3819045 | 0.84 | GRM5 (0.36) | GRM5GAAALDH1A1LMNATSHR | |
| SCHEMBL3813142 | 0.83 | GRM5 (0.33) | GRM5 | |
| SCHEMBL3820066 | 0.81 | ALDH1A1 (0.36) | PARP1GRM5ALDH1A1LMNATSHR | |
| SCHEMBL3816389 | 0.80 | NPC1 (0.35) | GRM5GAATP53ALDH1A1LMNA | |
| SCHEMBL3821039 | 0.80 | GRM5 (0.32) | PARP1GRM5ALDH1A1LMNAMAPT | |
| SCHEMBL3820352 | 0.80 | GRM5 (0.38) | GRM5MAPT | |
| SCHEMBL3819025 | 0.80 | DRD1 (0.40) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | claimed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |