Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 4/20 | 0.33 |
| ▸ | F11 | P03951 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 3/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3812787 | 0.89 | TNKS (0.37) | GRM5ALDH1A1LMNATSHRTP53 | |
| SCHEMBL1010374 | 0.86 | GRM5 (0.43) | MAPK1NPSR1GRM5ALDH1A1LMNA | |
| SCHEMBL3815643 | 0.84 | MAPT (0.38) | MAPK1NPSR1PROKR1GRM5ALDH1A1 | |
| SCHEMBL3819163 | 0.83 | MAPK1 (0.33) | MAPK1NPSR1PROKR1MGLL | |
| SCHEMBL3820067 | 0.83 | DRD1 (0.42) | MAPK1NPSR1KLKB1F11GRM5 | |
| SCHEMBL3813529 | 0.82 | F11 (0.40) | MAPK1NPSR1KLKB1F11GRM5 | |
| SCHEMBL3816988 | 0.81 | F11 (0.39) | MAPK1NPSR1KLKB1F11GRM5 | |
| SCHEMBL3818785 | 0.80 | DRD1 (0.36) | MAPK1NPSR1KLKB1F11GRM5 | |
| SCHEMBL3817040 | 0.80 | MAPK1 (0.34) | MAPK1NPSR1GRM5MGLL | |
| SCHEMBL3815634 | 0.80 | MAPK1 (0.34) | MAPK1NPSR1PROKR1GRM5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | claimed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |