Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | STAT3 | P40763 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3817040 | 0.90 | MAPK1 (0.34) | GRM5PARP1MAPK1 | |
| SCHEMBL3813142 | 0.87 | GRM5 (0.33) | GRM5 | |
| SCHEMBL1011577 | 0.86 | GRM5 (0.47) | GRM5ALDH1A1MAPT | |
| SCHEMBL3819045 | 0.82 | GRM5 (0.36) | GRM5LMNAMAPK1HTTSTAT3 | |
| SCHEMBL3817104 | 0.81 | ALDH1A1 (0.36) | GRM5LMNAMAPK1HTTSTAT3 | |
| SCHEMBL3812787 | 0.80 | TNKS (0.37) | GRM5PARP1LMNAALDH1A1MAPT | |
| SCHEMBL3815429 | 0.80 | HTT (0.40) | GRM5LMNAMAPK1HTTKDM4E | |
| SCHEMBL3817616 | 0.80 | HTT (0.40) | GRM5LMNAMAPK1HTTALDH1A1 | |
| SCHEMBL3820066 | 0.80 | ALDH1A1 (0.36) | GRM5PARP1LMNAMAPK1STAT3 | |
| SCHEMBL1011176 | 0.79 | GRM5 (0.42) | GRM5LMNAMAPK1STAT3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | claimed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |