Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 6/20 | 0.58 |
| ▸ | CA9 | Q16790 | 6/20 | 0.58 |
| ▸ | CA1 | P00915 | 5/20 | 0.58 |
| ▸ | CA2 | P00918 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | CA7 | P43166 | 2/20 | 0.50 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | CASP1 | P29466 | 2/20 | 0.42 |
| ▸ | CASP7 | P55210 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2216616 | 1.00 | CA12 (0.58) | CA12CA9CA1CA2KMT2A | |
| SCHEMBL22078960 | 1.00 | CA12 (0.58) | CA12CA9CA1CA2KMT2A | |
| SCHEMBL30434987 | 1.00 | CA12 (0.58) | CA12CA9CA1CA2KMT2A | |
| SCHEMBL2287566 | 1.00 | CA12 (0.58) | CA12CA9CA1CA2KMT2A | |
| SCHEMBL8570406 | 1.00 | CA12 (0.58) | CA12CA9CA1CA2KMT2A | |
| SCHEMBL24426595 | 1.00 | CA12 (0.58) | CA12CA9CA1CA2KMT2A | |
| SCHEMBL26356083 | 0.86 | KMT2A (0.62) | CA12CA9CA1CA2KMT2A | |
| SCHEMBL16098409 | 0.86 | KMT2A (0.50) | CA12CA9CA1CA2KMT2A | |
| SCHEMBL3074305 | 0.86 | KMT2A (0.50) | CA12CA9CA1CA2KMT2A | |
| SCHEMBL23479723 | 0.85 | KMT2A (0.55) | CA12CA9CA1CA2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210196842-A1 | SITE-SPECIFIC RADIOFLUORINATION OF PEPTIDES WITH 8-[18F]-FLUOROOCTANOIC ACID CATALYZED BY LIPOIC ACID LIGASE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-07-01 | — | — | US | disclosed |
| WO-2017095806-A1 | SITE-SPECIFIC RADIOFLUORINATION OF PEPTIDES WITH 8-[18F]-FLUOROOCTANOIC ACID CATALYZED BY LIPOIC ACID LIGASE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-06-08 | — | — | WO | disclosed |
| US-9284541-B2 | Methods and compositions for protein labeling using lipoic acid ligases | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2016-03-15 | — | — | US | disclosed |
| US-20150125904-A1 | PROBE INCORPORATION MEDIATED BY ENZYMES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2015-05-07 | — | — | US | disclosed |
| EP-2825261-A1 | POLYPEPTIDES AND THEIR USE | Novabiotics Limited (GB) | 2015-01-21 | — | — | EP | disclosed |
| US-8871456-B2 | Probe incorporation mediated by enzymes | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2014-10-28 | — | — | US | disclosed |
| US-20140155321-A1 | Polypeptides and Their Use | NOVABIOTICS LIMITED (GB) | 2014-06-05 | — | — | US | disclosed |
| WO-2013148189-A1 | PROBE INCORPORATION MEDIATED BY ENZYMES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2013-10-03 | — | — | WO | disclosed |
| WO-2013136040-A1 | POLYPEPTIDES AND THEIR USE | NOVABIOTICS LIMITED (GB) | 2013-09-19 | — | — | WO | disclosed |
| WO-2013052851-A1 | METHODS AND COMPOSITIONS FOR POLYPEPTIDE AND PROTEIN LABELING USING LIPOIC ACID LIGASES SPECIFIC TO RESORUFIN | MASSACHUSETTS INISTITUTE OF TECHNOLOGY (US) | 2013-04-11 | — | — | WO | disclosed |
| US-20120129159-A1 | METHODS AND COMPOSITIONS FOR PROTEIN LABELING USING LIPOIC ACID LIGASES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-05-24 | — | — | US | disclosed |
| US-20120083599-A1 | Biomolecular Labelling Using Multifunctional Biotin Analogues | UNIVERSITY OF NOTTINGHAM (GB) | 2012-04-05 | — | — | US | disclosed |
| US-8137925-B2 | Methods and compositions for protein labeling using lipoic acid ligases | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2012-03-20 | — | — | US | disclosed |
| EP-2408783-A2 | BIOMOLECULAR LABELLING USING MULTIFUNCTIONAL BIOTIN ANALOGUES | University Of Nottingham (GB) | 2012-01-25 | — | — | EP | disclosed |
| WO-2010106347-A2 | BIOMOLECULAR LABELLING USING MULTIFUNCTIONAL BIOTIN ANALOGUES | UNIVERSITY OF NOTTINGHAM (GB) | 2010-09-23 | — | — | WO | disclosed |
| US-20090149631-A1 | Methods and compositions for protein labeling using lipoic acid ligases | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2009-06-11 | — | — | US | disclosed |
| WO-2009064366-A2 | METHODS AND COMPOSITIONS FOR PROTEIN LABELING USING LIPOIC ACID LIGASES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2009-05-22 | — | — | WO | disclosed |
| US-7172877-B2 | Methods and compositions for peptide and protein labeling | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2007-02-06 | — | — | US | disclosed |
| US-20050233389-A1 | Methods and compositions for peptide and protein labeling | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2005-10-20 | — | — | US | disclosed |
| US-20040209317-A1 | Methods and compositions for peptide and protein labeling | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2004-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120129159-A1 | METHODS AND COMPOSITIONS FOR PROTEIN LABELING USING LIPOIC ACID LIGASES | LARS1, ACSL5, RARS1 | CA12 4555/4885CA9 4473/4885CA1 4000/4885 |
| US-20050233389-A1 | Methods and compositions for peptide and protein labeling | HLCS, BTD, QPCTL | CA12 3970/4885CA9 4481/4885CA1 3860/4885 |
| US-20120083599-A1 | Biomolecular Labelling Using Multifunctional Biotin Analogues | BTD, URB2, RAET1L | CA12 3329/4885CA9 4783/4885CA1 4710/4885 |
| US-20090149631-A1 | Methods and compositions for protein labeling using lipoic acid ligases | HLCS, ACSL5, ACSL1 | CA12 3961/4885CA9 3325/4885CA1 3341/4885 |
| US-20210196842-A1 | SITE-SPECIFIC RADIOFLUORINATION OF PEPTIDES WITH 8-[18F]-FLUOROOCTANOIC ACID CATALYZED BY LIPOIC ACID LIGASE | DLAT, FABP7, ACSL1 | CA12 1081/4885CA9 1554/4885CA1 358/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.