ACSL5 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Losmapimod (SCHEMBL1070401)	1.00	1/20
Losmapimod (SCHEMBL29367949)	1.00	1/20
Losmapimod (SCHEMBL29888732)	1.00	1/20
SCHEMBL20448678	0.86	1/20
SCHEMBL20883154	0.85	1/20
SCHEMBL20460539	0.84	1/20
SCHEMBL3427536	0.84	1/20
SCHEMBL3427034	0.83	1/20
SCHEMBL3409067	0.81	1/20
SCHEMBL3431414	0.80	1/20
SCHEMBL3429819	0.80	1/20
SCHEMBL6873218	0.79	1/20
SCHEMBL22764235	0.79	1/20
SCHEMBL3405486	0.79	1/20
SCHEMBL3429198	0.78	1/20
SCHEMBL3407363	0.78	1/20
SCHEMBL3535412	0.77	1/20
SCHEMBL20448612	0.77	1/20
SCHEMBL3408716	0.76	1/20
SCHEMBL3410765	0.76	1/20

Clinical trials — most relevant to ACSL5 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effects of Fenofibrate Therapy in Diabetic Nephropathy	PHASE3	UNKNOWN
Bezafibrate Trial in CPT2 Deficiency	PHASE3	UNKNOWN
Metabolic Cofactor Supplementation in Obese Patients With Non-Alcoholic Fatty Liver Disease	PHASE2	COMPLETED
Liver Positron Emission Tomography (PET) Study of Non Alcoholic Fatty Liver Disease	EARLY_PHASE1	COMPLETED
Fatty Acid Oxidation Defects and Insulin Sensitivity	nan	COMPLETED
Androgens and NAFLD Longitudinal Cohort Study	nan	RECRUITING
Fish Oil and Nonalcoholic Fatty Liver Disease (NAFLD) Study	nan	COMPLETED
Screening of Healthy Adults for Genetic Variations That Control Fatty Acid Processing	nan	COMPLETED
Familial Partial Lipodystrophy Study	nan	COMPLETED
Fatty Acid Metabolism and Insulin Sensitivity: the Role of Endurance Exercise	nan	COMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Effects of Fish Oils on Inflammation and Insulin Resistance	nan	COMPLETED
Lifestyle Intervention in Preparation for Pregnancy (LIPP)	nan	COMPLETED
Genetic and Environmental Determinants of Triglycerides (GOLDN)	nan	COMPLETED
Exercise Intolerance Study in Long Chain Fatty Acid Oxidation Disorders	nan	RECRUITING
Effect of Dietary SFA and Fructose on Hepatic Insulin Sensitivity	nan	COMPLETED
The Roles of SAH Gene Family in Athrogenic Dyslipidemia in Postmenopausal Women	nan	UNKNOWN
Glycemic Index/Saturated Fatty Acid Diet and Hepatic Fat	nan	COMPLETED
Omega-3 vs Very Low Calorie Diet for Liver Size Reduction	nan	UNKNOWN
EPICO: (Study for the Pro-resolution of Chronic Inflammation in Obesity. Original Acronym From Spanish)	nan	UNKNOWN
Dietary Fatty Acids, PPAR Activated Genes, and CHD	nan	COMPLETED
Effect of Age on Glucose and Lipid Metabolism	nan	COMPLETED
Acute Fatty Acid Intervention Study (AFAST)	nan	COMPLETED
De Novo Lipogenesis in Severity of NAFLD	nan	COMPLETED
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population	nan	UNKNOWN
Hepatic Glycogen and Fat Oxidation	nan	COMPLETED
Impact Of Choline in Patients With NAFLD	nan	UNKNOWN
Tissue Lipids and Insulin Resistance	nan	WITHDRAWN
Hepatic Energy Fluxes in NASH and NAS Patients	nan	ACTIVE_NOT_RECRUITING
Metabolic Effects of Medium-Chain Fatty Acids in Patients With Medium-Chain Acyl-CoA Dehydrogenase Deficiency and Healthy Individuals	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a ACSL5 binder may also engage these)

Protein	Name	Similarity
O88813	—	0.998	O88813 →
Q8JZR0	—	0.994	Q8JZR0 →
ACSL3	Fatty acid CoA ligase Acsl3	0.990	landscape →
Q5R668	—	0.990	Q5R668 →
O35547	—	0.989	O35547 →
Q63151	—	0.988	Q63151 →
Q9CAP8	—	0.988	Q9CAP8 →
Q8LKS5	—	0.985	Q8LKS5 →
Q9QUJ7	—	0.984	Q9QUJ7 →
Q8LPS1	—	0.984	Q8LPS1 →
Q9CZW4	—	0.983	Q9CZW4 →
ACSL4	Long-chain-fatty-acid--CoA ligase 4	0.982	landscape →
P18163	—	0.978	P18163 →
Q9SJD4	—	0.978	Q9SJD4 →
P41216	—	0.976	P41216 →
Q9JID6	—	0.974	Q9JID6 →
I3PB37	—	0.973	I3PB37 →
Q9C7W4	—	0.973	Q9C7W4 →
Q9M0X9	—	0.971	Q9M0X9 →
Q9P7D7	—	0.971	Q9P7D7 →
Q99KR3	—	0.969	Q99KR3 →
Q55DR6	—	0.969	Q55DR6 →
M4ISH1	—	0.969	M4ISH1 →
Q9T009	—	0.969	Q9T009 →
Q9XIA9	—	0.969	Q9XIA9 →
ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.968	landscape →
O24146	—	0.968	O24146 →
P97524	—	0.968	P97524 →
Q64602	—	0.967	Q64602 →
Q84P21	—	0.967	Q84P21 →