RARS1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Adenosine Phosphate (SCHEMBL15670688)	0.53	2/20
SCHEMBL30817311	1.00	1/20
SCHEMBL4253015	0.81	1/20
SCHEMBL13773212	0.81	1/20
SCHEMBL13773213	0.81	1/20
SCHEMBL13773214	0.81	1/20
SCHEMBL29390953	0.81	1/20
SCHEMBL5063184	0.80	1/20
SCHEMBL5063189	0.80	1/20
SCHEMBL3187637	0.79	1/20
SCHEMBL3187665	0.79	1/20
SCHEMBL21068060	0.79	1/20
SCHEMBL13773209	0.78	1/20
SCHEMBL13773210	0.78	1/20
SCHEMBL13773211	0.78	1/20
SCHEMBL5067246	0.78	1/20
SCHEMBL3500697	0.77	1/20
SCHEMBL178823	0.77	1/20
SCHEMBL178824	0.77	1/20
SCHEMBL4313369	0.76	1/20

Clinical trials — most relevant to RARS1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Management of Retinitis Pigmentosa Via Combination of Wharton's Jelly-derived Mesenchymal Stem Cells and Magnovision	PHASE3	COMPLETED
Efficacy and Safety of Drug Combination Therapy of Isotretinoin and Some Antifungal Drugs as A Potential Aerosol Therapy for COVID-19 : An Innovative Therapeutic Approach COVID-19	PHASE2	UNKNOWN
A Pilot Study of an Antioxidant Cocktail vs. Placebo in the Treatment of Children and Adolescents With Rett Syndrome	PHASE2	NOT_YET_RECRUITING
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
Treatment of Acute Myeloid Leukemia With Arsenic and All-trans Retinoid Acid	PHASE1	UNKNOWN
Gene Therapy for the Treatment of Fanconi's Anemia Type C	PHASE1	COMPLETED
Mechanisms of Inherited Retinal Dystrophies Using Whole Genome Sequencing and in Vitro and in Vivo Models	nan	COMPLETED
Natural History Study of Leukoencephalopathy With Brainstem and Spinal Cord Involvement and Lactate Elevation (LBSL)	nan	RECRUITING
Quantifying Disease Progression in LBSL	nan	UNKNOWN
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM)	nan	COMPLETED
Impact of Mutations in Aminoacyl tRNA Synthetases on Protein Translation and Cellular Stress	nan	WITHDRAWN
New Genes Involved in Molecular Etiology of Rett Syndrome Through DNA Microarray Comparative Genomic Hybridization	nan	COMPLETED
Genetic Analysis of Fraser Syndrome and Fryns Syndrome	nan	COMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Effect of Short-Term Exercise Training on ATP Synthesis in Relatives of Type 2 Diabetic Humans	nan	COMPLETED
Diagnosis of RSTS: Identification of the Acetylation Profiles as Epigenetic Markers for Assessing Causality of CREBBP and EP300 Variants.	nan	UNKNOWN
Calf Muscle Strength in Mitochondrial Diseases	nan	COMPLETED
The Role of Maspin in Colorectal Carcinoma, an Immunohistochemical Study	nan	NOT_YET_RECRUITING
Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases	nan	UNKNOWN
Mitochondrial Disease-associated ImmunoDeficiencies	nan	RECRUITING
Diagnosis and Phenotype Characterisation Using Genomics in Patients With Inherited Bone Marrow Failure (IBMDx Study)	nan	RECRUITING
Exercise-mediated Rescue of Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic Leukemia	nan	NOT_YET_RECRUITING
Multi-Dimensional Genomic Dissection of Ring Chromosome 14 Syndrome	nan	ACTIVE_NOT_RECRUITING
Nicotinamide Riboside and Mitochondrial Biogenesis	nan	COMPLETED
Drug Repurposing for Mitochondrial Disorders Using iPSCs Derived Neural Cells	nan	RECRUITING
McArdle Disease Treatment by Ketogenic Diet	nan	COMPLETED
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
Replacement of Vitamin D in Patients With Active Tuberculosis	nan	COMPLETED
Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a RARS1 binder may also engage these)

Protein	Name	Similarity
Q5RA20	—	1.000	Q5RA20 →
Q5ZM11	—	1.000	Q5ZM11 →
A7YW98	—	1.000	A7YW98 →
P37880	—	1.000	P37880 →
Q9D0I9	—	1.000	Q9D0I9 →
P40329	—	1.000	P40329 →
Q6P1S4	—	1.000	Q6P1S4 →
Q9C713	—	1.000	Q9C713 →
C4K487	—	0.999	C4K487 →
O23247	—	0.999	O23247 →
Q9VXN4	—	0.999	Q9VXN4 →
Q7VP38	—	0.998	Q7VP38 →
P43832	—	0.997	P43832 →
Q6MLI2	—	0.997	Q6MLI2 →
Q73H00	—	0.997	Q73H00 →
Q2SMY0	—	0.997	Q2SMY0 →
B0UUF1	—	0.997	B0UUF1 →
Q8SRD8	—	0.997	Q8SRD8 →
O84304	—	0.996	O84304 →
A6VNB3	—	0.996	A6VNB3 →
A5UJ40	—	0.996	A5UJ40 →
B3CNK5	—	0.996	B3CNK5 →
Q4QL12	—	0.996	Q4QL12 →
Q66AV1	—	0.996	Q66AV1 →
Q5L5J6	—	0.996	Q5L5J6 →
Q8ZEV7	—	0.995	Q8ZEV7 →
B0BBT3	—	0.995	B0BBT3 →
C6DFD9	—	0.995	C6DFD9 →
A6UD99	—	0.995	A6UD99 →
A8FQM2	—	0.995	A8FQM2 →