Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 5/20 | 0.33 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 3/20 | 0.32 |
| ▸ | DHCR7 | Q9UBM7 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL381359 | 1.00 | KIT (0.33) | KITFFAR4PTGDRTRPV4HTR2A | |
| SCHEMBL381541 | 0.90 | MAPT (0.34) | DHCR7TACR1 | |
| SCHEMBL381812 | 0.90 | CHRM3 (0.33) | — | |
| SCHEMBL381236 | 0.88 | FFAR4 (0.35) | KITFFAR4PTGDRTRPV4HTR2A | |
| SCHEMBL381556 | 0.88 | FFAR4 (0.35) | KITFFAR4PTGDRTRPV4HTR2A | |
| SCHEMBL380490 | 0.87 | AKR1C2 (0.37) | FFAR4 | |
| SCHEMBL380833 | 0.86 | MCHR1 (0.33) | — | |
| SCHEMBL381332 | 0.86 | MCHR1 (0.34) | — | |
| SCHEMBL381499 | 0.86 | MCHR1 (0.34) | — | |
| SCHEMBL13031220 | 0.84 | HTR2A (0.35) | KITFFAR4PTGDRHTR2ADHCR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049513-B1 | PIPERIDINYL SUBSTITUTED PYRROLIDINONES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | LILLY CO ELI (US) | 2012-01-25 | — | — | EP | claimed |