Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 10/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 3/20 | 0.32 |
| ▸ | CNR2 | P34972 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL381541 | 0.94 | MAPT (0.34) | HSD11B1TP53 | |
| SCHEMBL381332 | 0.91 | MCHR1 (0.34) | CHRM3HSD11B1CNR1 | |
| SCHEMBL381499 | 0.91 | MCHR1 (0.34) | CHRM3HSD11B1CNR1 | |
| SCHEMBL381971 | 0.91 | CHRM3 (0.33) | CHRM3HSD11B1ROCK2HDAC3HDAC1 | |
| SCHEMBL381487 | 0.91 | ROCK2 (0.36) | CHRM3HSD11B1ROCK2TP53CNR1 | |
| SCHEMBL380490 | 0.91 | AKR1C2 (0.37) | CHRM3 | |
| SCHEMBL380833 | 0.90 | MCHR1 (0.33) | CHRM3HSD11B1ROCK2 | |
| SCHEMBL381359 | 0.90 | KIT (0.33) | — | |
| SCHEMBL381324 | 0.90 | KIT (0.33) | — | |
| SCHEMBL381162 | 0.86 | TP53 (0.41) | HSD11B1HDAC3HDAC1HDAC2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049513-B1 | PIPERIDINYL SUBSTITUTED PYRROLIDINONES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | LILLY CO ELI (US) | 2012-01-25 | — | — | EP | claimed |