Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 4/20 | 0.34 |
| ▸ | CTSS | P25774 | 2/20 | 0.33 |
| ▸ | FPR1 | P21462 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
| ▸ | PPARD | Q03181 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL381499 | 1.00 | MCHR1 (0.34) | MCHR1CTSSFPR1FPR2SCN9A | |
| SCHEMBL381812 | 0.91 | CHRM3 (0.33) | CNR1HSD11B1CHRM3 | |
| SCHEMBL381134 | 0.91 | CNR1 (0.36) | MCHR1SCN9ACNR1DRD4CHRM3 | |
| SCHEMBL380490 | 0.91 | AKR1C2 (0.37) | MCHR1SCN9ACHRM3 | |
| SCHEMBL381541 | 0.90 | MAPT (0.34) | MCHR1HSD11B1HRH3 | |
| SCHEMBL381239 | 0.87 | MCHR1 (0.36) | MCHR1CTSSFPR1FPR2CNR1 | |
| SCHEMBL381008 | 0.87 | MCHR1 (0.36) | MCHR1CTSSFPR1FPR2CNR1 | |
| SCHEMBL381324 | 0.86 | KIT (0.33) | — | |
| SCHEMBL380833 | 0.86 | MCHR1 (0.33) | MCHR1HSD11B1HRH3CHRM3 | |
| SCHEMBL381359 | 0.86 | KIT (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049513-B1 | PIPERIDINYL SUBSTITUTED PYRROLIDINONES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | LILLY CO ELI (US) | 2012-01-25 | — | — | EP | claimed |