Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.31 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | TACR2 | P21452 | 1/20 | 0.30 |
| ▸ | TACR1 | P25103 | 1/20 | 0.30 |
| ▸ | TACR3 | P29371 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | HRH1 | P35367 | 1/20 | 0.30 |
| ▸ | CCR3 | P51677 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | EBP | Q15125 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL381812 | 0.94 | CHRM3 (0.33) | HSD11B1TP53 | |
| SCHEMBL381499 | 0.90 | MCHR1 (0.34) | HSD11B1MCHR1HRH3 | |
| SCHEMBL381359 | 0.90 | KIT (0.33) | TACR1DHCR7 | |
| SCHEMBL381324 | 0.90 | KIT (0.33) | TACR1DHCR7 | |
| SCHEMBL380833 | 0.90 | MCHR1 (0.33) | HSD11B1MCHR1HRH3HRH1 | |
| SCHEMBL381332 | 0.90 | MCHR1 (0.34) | HSD11B1MCHR1HRH3 | |
| SCHEMBL380490 | 0.90 | AKR1C2 (0.37) | AKR1C2AKR1C1MCHR1 | |
| SCHEMBL13031212 | 0.86 | MAPT (0.43) | MAPTHSD11B1CXCR3TP53HRH1 | |
| SCHEMBL381000 | 0.86 | MAPT (0.43) | MAPTHSD11B1CXCR3TP53HRH1 | |
| SCHEMBL381006 | 0.85 | NAMPT (0.34) | CXCR3HRH3HRH1CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049513-B1 | PIPERIDINYL SUBSTITUTED PYRROLIDINONES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | LILLY CO ELI (US) | 2012-01-25 | — | — | EP | claimed |