Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | ESR1 | P03372 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6734560 | 0.84 | ALDH1A1 (0.53) | NPC1KDM4ELMNASMN1; SMN2TSHR | |
| SCHEMBL6734561 | 0.84 | ALDH1A1 (0.53) | NPC1KDM4ELMNASMN1; SMN2TSHR | |
| SCHEMBL6734564 | 0.84 | ALDH1A1 (0.53) | NPC1KDM4ELMNASMN1; SMN2TSHR | |
| SCHEMBL1306294 | 0.78 | ALDH1A1 (0.46) | NPC1RAB9AKDM4ELMNASMN1; SMN2 | |
| SCHEMBL1306293 | 0.78 | ALDH1A1 (0.46) | NPC1RAB9AKDM4ELMNASMN1; SMN2 | |
| SCHEMBL6057132 | 0.76 | TSHR (0.74) | NPC1RAB9ACASP1KDM4ELMNA | |
| SCHEMBL19649668 | 0.75 | LMNA (0.72) | NPC1RAB9ACASP1KDM4ELMNA | |
| SCHEMBL3137370 | 0.74 | SMN1; SMN2 (0.51) | NPC1RAB9ACASP1KDM4ELMNA | |
| SCHEMBL3137385 | 0.74 | SMN1; SMN2 (0.51) | NPC1RAB9ACASP1KDM4ELMNA | |
| SCHEMBL3137378 | 0.74 | SMN1; SMN2 (0.51) | NPC1RAB9ACASP1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2089354-A1 | NAPHTHALENYLOXYPROPENYL DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | Korea Research Institute Of Chemical Technology (KR) | 2009-08-19 | — | — | EP | disclosed |
| WO-2008054154-A1 | NAPHTHALENYLOXYPROPENYL DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2008-05-08 | — | — | WO | disclosed |