Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.46 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.46 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.46 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | CA1 | P00915 | 3/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6734560 | 1.00 | ALDH1A1 (0.53) | ALDH1A1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL6734561 | 1.00 | ALDH1A1 (0.53) | ALDH1A1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL1306293 | 0.87 | ALDH1A1 (0.46) | ALDH1A1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL1306294 | 0.87 | ALDH1A1 (0.46) | ALDH1A1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL6740625 | 0.84 | KMT2A (0.51) | MAPTLMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6740629 | 0.84 | KMT2A (0.51) | MAPTLMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6741190 | 0.84 | KMT2A (0.51) | MAPTLMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL3813626 | 0.84 | NPC1 (0.52) | ALDH1A1MAPTLMNAKDM4ESMN1; SMN2 | |
| SCHEMBL20048294 | 0.83 | GRIK1 (0.43) | ALDH1A1KDM4E | |
| SCHEMBL6299382 | 0.82 | RECQL (0.53) | ALDH1A1MAPTSMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6686503-B2 | SPLITITNG FROM SOLID SUPPORT; METHYLATION | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-02-03 | — | — | US | disclosed |
| US-20010041345-A1 | Methods for the synthesis of highly substituted 2,4-dioxopiperidine libraries | CHAI WENYING (US) | 2001-11-15 | — | — | US | disclosed |
| US-6288235-B1 | MULTISTAGE REACTION WITH AMIDATION, CLEAVAGE FROM RESIN SUPPORT AND METHYLATION THEN CONDENSATION OF METHYL ESTER TO GIVE 2,4-DIOXOPIPERIDINE COMPOUNDS | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2001-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010041345-A1 | Methods for the synthesis of highly substituted 2,4-dioxopiperidine libraries | DHPS, DRD4, DRD2 | ALDH1A1 857/4885GRIN2D 378/4885GRIN3B 1511/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.