Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1285638 | 0.84 | SRC (0.42) | ALOX15HTTPDE4BGABRA1GABRG2 | |
| SCHEMBL31429017 | 0.81 | MEN1 (0.51) | ALOX15HTTGABRA1GABRG2GABRB3 | |
| SCHEMBL4987847 | 0.80 | NCF1 (0.46) | ALOX15HTTGABRA1GABRG2GABRB3 | |
| SCHEMBL8390404 | 0.78 | GABRA1 (0.50) | ALOX15GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL24977227 | 0.78 | KDM4E (0.40) | ALOX15HTTGABRA1GABRG2GABRB3 | |
| SCHEMBL31428804 | 0.78 | KDM4E (0.40) | ALOX15HTTGABRA1GABRG2GABRB3 | |
| SCHEMBL909531 | 0.78 | CA12 (0.43) | ALOX15HTTGABRA1GABRG2GABRB3 | |
| SCHEMBL27609051 | 0.77 | GRM1 (0.40) | ALOX15HTTGABRA1GABRG2GABRB3 | |
| SCHEMBL1645338 | 0.76 | HPGDS (0.42) | ALOX15HTTGABRA1GABRG2GABRB3 | |
| SCHEMBL1839209 | 0.76 | CA12 (0.41) | ALOX15HTTPDE4BGABRA1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091944-A2 | SUBSTITUTED BICYCLOCARBOXYAMIDE COMPOUNDS | Pfizer, Inc. (US) | 2009-08-26 | — | — | EP | disclosed |
| WO-2008059370-A2 | SUBSTITUTED BICYCLOCARBOXYAMIDE COMPOUNDS | PFIZER JAPAN INC. (JP) | 2008-05-22 | — | — | WO | disclosed |