Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.45 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 10/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 6/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 6/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 6/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 6/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 6/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.38 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5317298 | 0.80 | OPRM1 (0.41) | OPRM1OPRD1OPRK1OPRL1SSTR5 | |
| SCHEMBL14840627 | 0.79 | OPRM1 (0.43) | OPRM1OPRD1OPRK1OPRL1SSTR5 | |
| SCHEMBL20147416 | 0.79 | OPRM1 (0.50) | OPRM1OPRD1OPRK1OPRL1SSTR5 | |
| SCHEMBL5314043 | 0.78 | PPARG (0.43) | OPRM1OPRD1OPRK1OPRL1SSTR5 | |
| SCHEMBL20147864 | 0.76 | OPRM1 (0.48) | OPRM1OPRD1OPRK1OPRL1SSTR5 | |
| SCHEMBL27967465 | 0.74 | CYP46A1 (0.48) | OPRM1OPRD1OPRK1OPRL1SSTR5 | |
| SCHEMBL28914608 | 0.74 | OPRL1 (0.43) | OPRM1OPRD1OPRK1OPRL1SSTR5 | |
| SCHEMBL13231734 | 0.73 | OPRM1 (0.43) | OPRM1OPRD1OPRK1OPRL1SSTR5 | |
| SCHEMBL4634537 | 0.73 | CYP46A1 (0.50) | OPRM1OPRD1OPRK1OPRL1SSTR5 | |
| SCHEMBL6810808 | 0.72 | GRIN2B (0.47) | OPRM1GRIN2BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931348-A4 | MONOCYCLIC AND BICYCLIC COMPOUNDS AND METHODS OF USE | CHEMOCENTRYX INC (US) | 2009-08-12 | — | — | EP | disclosed |
| EP-1931348-A2 | MONOCYCLIC AND BICYCLIC COMPOUNDS AND METHODS OF USE | ChemoCentryx Inc (US) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007022257-A2 | MONOCYCLIC AND BICYCLIC COMPOUNDS AND METHODS OF USE | CHEMOCENTRYX, INC. (US) | 2007-02-22 | — | — | WO | disclosed |