Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 4/20 | 0.58 |
| ▸ | BCL2 | P10415 | 2/20 | 0.53 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.53 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.49 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | IDH1 | O75874 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8930618 | 0.88 | BCL2 (0.61) | PTPN1BCL2BCL2L1PTPN2PTPN6 | |
| SCHEMBL10873237 | 0.84 | PTPN1 (0.72) | PTPN1BCL2BCL2L1PTPN2PTPN6 | |
| SCHEMBL12922967 | 0.84 | PTPN1 (0.67) | PTPN1BCL2BCL2L1PTPN2PTPN6 | |
| SCHEMBL15313782 | 0.84 | PTPN1 (0.50) | PTPN1BCL2BCL2L1PTPN2PTPN6 | |
| SCHEMBL15313694 | 0.80 | LTA4H (0.52) | PTPN1BCL2BCL2L1PTPN2PTPN6 | |
| SCHEMBL10903447 | 0.79 | PTPN1 (0.61) | PTPN1BCL2BCL2L1PTPN2PTPN6 | |
| SCHEMBL10051839 | 0.79 | PTPN1 (0.61) | PTPN1BCL2BCL2L1PTPN2PTPN6 | |
| SCHEMBL3821734 | 0.79 | BCL2 (0.43) | PTPN1BCL2BCL2L1PTPN2PTPN6 | |
| SCHEMBL3815076 | 0.77 | IGF1R (0.45) | PTPN1BCL2BCL2L1PTPN2PTPN6 | |
| SCHEMBL13609112 | 0.77 | ESR1 (0.59) | BCL2BCL2L1ALOX5MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |