Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 3/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313782 | 0.84 | PTPN1 (0.50) | BCL2PTPN1ELANEPTPN2PTPN6 | |
| SCHEMBL15313768 | 0.80 | BCL2 (0.44) | BCL2PTPN1PTPN2PTPN6BCL2L1 | |
| SCHEMBL3821734 | 0.78 | BCL2 (0.43) | BCL2PTPN1ELANEPTPN2PTPN6 | |
| SCHEMBL3815076 | 0.77 | IGF1R (0.45) | BCL2PTPN1PTPN2PTPN6BCL2L1 | |
| SCHEMBL15313769 | 0.76 | BCL2 (0.41) | BCL2PTPN1PTPN2PTPN6BCL2L1 | |
| SCHEMBL15313820 | 0.75 | BCL2 (1.00) | BCL2BCL2L1 | |
| SCHEMBL3819520 | 0.72 | RARB (0.46) | PTGS1PTGS2 | |
| SCHEMBL15314346 | 0.72 | RARB (0.46) | PTGS1PTGS2 | |
| SCHEMBL15313695 | 0.72 | PTPN1 (0.58) | BCL2PTPN1PTPN2PTPN6BCL2L1 | |
| SCHEMBL8930618 | 0.71 | BCL2 (0.61) | BCL2PTPN1PTPN2PTPN6BCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |