Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ITGAV | P06756 | 1/20 | 0.34 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.34 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19244883 | 0.91 | OPRM1 (0.41) | MEN1KMT2AOPRM1CXCL8ADRB2 | |
| SCHEMBL380995 | 0.90 | KMT2A (0.36) | MEN1KMT2AITGAVOPRM1CXCL8 | |
| SCHEMBL417713 | 0.82 | OPRM1 (0.38) | MEN1KMT2AMAPK1ITGAVTAS1R3 | |
| SCHEMBL19244878 | 0.81 | OPRM1 (0.39) | MEN1KMT2AOPRM1CXCL8ADRB2 | |
| SCHEMBL19244855 | 0.80 | MEN1 (0.41) | MEN1KMT2AMAPK1TAS1R3TAS1R1 | |
| SCHEMBL19244867 | 0.80 | OPRM1 (0.42) | OPRM1CXCL8ADRB2ADRB1CYP2D6 | |
| SCHEMBL382150 | 0.80 | CNR2 (0.39) | MEN1KMT2AMAPK1HSD11B1ALDH1A1 | |
| SCHEMBL381393 | 0.79 | NISCH (0.43) | MEN1KMT2AMAPK1TAS1R3TAS1R1 | |
| SCHEMBL381228 | 0.78 | MEN1 (0.39) | MEN1KMT2AMAPK1TAS1R3TAS1R1 | |
| SCHEMBL19244879 | 0.78 | MEN1 (0.37) | MEN1KMT2AMAPK1TAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408751-B1 | Substituted 2-acetamido-5-aryl-1,2,4-triazolones and use thereof | BAYER IP GMBH (DE) | 2017-08-23 | — | — | EP | disclosed |
| EP-2408751-A1 | Substituted 2-acetamido-5-aryl-1,2,4-triazolones and use thereof | Bayer Pharma Aktiengesellschaft (DE) | 2012-01-25 | — | — | EP | disclosed |
| WO-2010105770-A1 | SUBSTITUTED 2-ACETAMIDO-5-ARYL-1,2,4-TRIAZOLONES AND USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-09-23 | — | — | WO | disclosed |