Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 7/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ITGAV | P06756 | 1/20 | 0.34 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.34 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19244878 | 0.86 | OPRM1 (0.39) | OPRM1MEN1KMT2ATMEM97SIGMAR1 | |
| SCHEMBL381522 | 0.82 | MEN1 (0.35) | OPRM1MEN1KMT2AMAPK1ITGAV | |
| SCHEMBL380995 | 0.81 | KMT2A (0.36) | OPRM1MEN1KMT2AITGAV | |
| SCHEMBL19244855 | 0.80 | MEN1 (0.41) | OPRM1MEN1KMT2AMAPK1TAS1R3 | |
| SCHEMBL381393 | 0.79 | NISCH (0.43) | MEN1KMT2AMAPK1TAS1R3TAS1R1 | |
| SCHEMBL381228 | 0.78 | MEN1 (0.39) | OPRM1MEN1KMT2AMAPK1TAS1R3 | |
| SCHEMBL19244879 | 0.78 | MEN1 (0.37) | MEN1KMT2AMAPK1TAS1R3TAS1R1 | |
| SCHEMBL19244810 | 0.76 | OPRM1 (0.48) | OPRM1KMT2AOPRK1 | |
| SCHEMBL10217238 | 0.75 | CYP1A2 (0.45) | OPRM1MEN1KMT2AOPRD1OPRK1 | |
| SCHEMBL16674049 | 0.75 | MEN1 (0.37) | MEN1KMT2ATAS1R3TAS1R1TAS1R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408751-B1 | Substituted 2-acetamido-5-aryl-1,2,4-triazolones and use thereof | BAYER IP GMBH (DE) | 2017-08-23 | — | — | EP | disclosed |
| EP-2408751-A1 | Substituted 2-acetamido-5-aryl-1,2,4-triazolones and use thereof | Bayer Pharma Aktiengesellschaft (DE) | 2012-01-25 | — | — | EP | disclosed |
| WO-2010105770-A1 | SUBSTITUTED 2-ACETAMIDO-5-ARYL-1,2,4-TRIAZOLONES AND USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-09-23 | — | — | WO | disclosed |