Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | MDH2 | P40926 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | CFTR | P13569 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.49 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.48 |
| ▸ | DNASE1 | P24855 | 1/20 | 0.48 |
| ▸ | FEN1 | P39748 | 1/20 | 0.48 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16112737 | 0.81 | ALDH1A1 (0.56) | ALDH1A1HPGDCYP1A2MEN1ALOX12 | |
| SCHEMBL10835850 | 0.78 | ALDH1A1 (0.59) | ALDH1A1HPGDCYP1A2MEN1ALOX12 | |
| SCHEMBL377150 | 0.77 | CFTR (0.67) | ALDH1A1HPGDCYP1A2MEN1ALOX12 | |
| SCHEMBL29551347 | 0.77 | CFTR (0.67) | ALDH1A1HPGDCYP1A2MEN1ALOX12 | |
| SCHEMBL18589525 | 0.76 | CYP1A2 (0.64) | ALDH1A1HPGDCYP1A2MEN1ALOX12 | |
| Hydrochloric Acid SCHEMBL9046989 | 0.76 | CFTR (0.65) | ALDH1A1HPGDCYP1A2MEN1ALOX12 | |
| Hydrochloric Acid SCHEMBL29766716 | 0.76 | CFTR (0.65) | ALDH1A1HPGDCYP1A2MEN1ALOX12 | |
| Hydrochloric Acid SCHEMBL30585295 | 0.76 | CFTR (0.65) | ALDH1A1HPGDCYP1A2MEN1ALOX12 | |
| SCHEMBL4537810 | 0.75 | CYP1A2 (0.62) | ALDH1A1HPGDCYP1A2MEN1ALOX12 | |
| SCHEMBL4452877 | 0.75 | KDM4E (0.77) | ALDH1A1HPGDCYP1A2MEN1ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10336703-B2 | Process for the synthesis of ivacaftor and related compounds | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2019-07-02 | — | — | US | disclosed |
| US-20180127373-A1 | PROCESS FOR THE SYNTHESIS OF IVACAFTOR AND RELATED COMPOUNDS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2018-05-10 | — | — | US | disclosed |
| WO-2016181414-A1 | PROCESS FOR THE SYNTHESIS OF IVACAFTOR AND RELATED COMPOUNDS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-11-17 | — | — | WO | disclosed |
| EP-1713803-B1 | 7-PHENYLAMINO-4-QUINOLONE-3-CARBOXYLIC ACID DERIVATIVES, METHODS FOR PRODUCTION AND USE THEREOF AS MEDICAMENTS | SANOFI AVENTIS DEUTSCHLAND (DE) | 2009-08-05 | — | — | EP | disclosed |
| US-7402674-B2 | 7-Phenylamino-4-quinolone-3-carboxylic acid derivatives, process for their preparation and their use as medicaments | SANOFI-AVENTIS DEUTSCHLAND GMBH, (DE) | 2008-07-22 | — | — | US | disclosed |
| US-7402674-B2 | 7-Phenylamino-4-quinolone-3-carboxylic acid derivatives, process for their preparation and their use as medicaments | SANOFI-AVENTIS DEUTSCHLAND GMBH, (DE) | 2008-07-22 | — | — | US | disclosed |
| US-7402674-B2 | 7-Phenylamino-4-quinolone-3-carboxylic acid derivatives, process for their preparation and their use as medicaments | SANOFI-AVENTIS DEUTSCHLAND GMBH, (DE) | 2008-07-22 | — | — | US | disclosed |
| CN-1914206-A | 7-phenylamino-4-quinolone-3-carboxylic acid derivatives, methods for production and use thereof as medicaments | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-02-14 | — | — | CN | disclosed |
| CN-1914206-A | 7-phenylamino-4-quinolone-3-carboxylic acid derivatives, methods for production and use thereof as medicaments | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-02-14 | — | — | CN | disclosed |
| EP-1713803-A1 | 7-PHENYLAMINO-4-QUINOLONE-3-CARBOXYLIC ACID DERIVATIVES, METHODS FOR PRODUCTION AND USE THEREOF AS MEDICAMENTS | Sanofi-Aventis Deutschland GmbH (DE) | 2006-10-25 | — | — | EP | disclosed |
| US-20050182085-A1 | 7-phenylamino-4-quinolone-3-carboxylic acid derivatives, process for their preparation and their use as medicaments | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2005-08-18 | — | — | US | disclosed |
| US-20050182085-A1 | 7-phenylamino-4-quinolone-3-carboxylic acid derivatives, process for their preparation and their use as medicaments | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2005-08-18 | — | — | US | disclosed |
| US-20050182085-A1 | 7-phenylamino-4-quinolone-3-carboxylic acid derivatives, process for their preparation and their use as medicaments | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2005-08-18 | — | — | US | disclosed |
| WO-2005073229-A1 | 7-PHENYLAMINO-4-QUINOLONE-3-CARBOXYLIC ACID DERIVATIVES, METHODS FOR PRODUCTION AND USE THEREOF AS MEDICAMENTS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2005-08-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10336703-B2 | Process for the synthesis of ivacaftor and related compounds | AVPR1A, ACVR1, AVPR2 | ALDH1A1 69/4885HPGD 2796/4885CYP1A2 393/4885 |
| US-20180127373-A1 | PROCESS FOR THE SYNTHESIS OF IVACAFTOR AND RELATED COMPOUNDS | AVPR1A, ACVR1, AVPR2 | ALDH1A1 69/4885HPGD 2796/4885CYP1A2 393/4885 |
| US-20050182085-A1 | 7-phenylamino-4-quinolone-3-carboxylic acid derivatives, process for their preparation and their use as medicaments | SLC5A2, CYP2A7, GLS | ALDH1A1 395/4885HPGD 254/4885CYP1A2 22/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.