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SCHEMBL3815554

SCHEMBL3815554

CC(C)(C)OC(=O)NCCNc1nc(NC(=O)C(F)(F)F)ccc1[N+](=O)[O-]

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LATS1 O95835 1/20 0.42
▸ BCHE P06276 1/20 0.40
▸ BRD4 O60885 3/20 0.40
▸ SIRT5 Q9NXA8 2/20 0.40
▸ MAPT P10636 2/20 0.39
▸ STK17B O94768 1/20 0.38
▸ STK17A Q9UEE5 1/20 0.38
▸ MALT1 Q9UDY8 1/20 0.37
▸ ADRA2A P08913 1/20 0.36
▸ DRD5 P21918 1/20 0.36
▸ DRD3 P35462 1/20 0.36
▸ P2RY6 Q15077 1/20 0.36
▸ FOLH1 Q04609 1/20 0.36
▸ EGFR P00533 1/20 0.35
▸ CA12 O43570 2/20 0.35
▸ CA1 P00915 2/20 0.35
▸ CA2 P00918 2/20 0.35
▸ CA9 Q16790 2/20 0.35
▸ ALDH1A1 P00352 1/20 0.35
▸ GLA P06280 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3816144 0.83 LATS1 (0.47) LATS1BCHEBRD4STK17BSTK17A
SCHEMBL3815550 0.82 MAPT (0.38) SIRT5MAPTFOLH1ALDH1A1GLA
SCHEMBL3813745 0.82 MAPT (0.57) LATS1BCHEBRD4MAPTSTK17B
SCHEMBL3812414 0.81 MAPT (0.44) LATS1BCHEBRD4MAPTSTK17B
SCHEMBL3408429 0.80 TXNRD1 (0.47) LATS1BCHEBRD4MAPTSTK17B
SCHEMBL1181351 0.78 MAPT (0.48) LATS1BCHEBRD4SIRT5MAPT
SCHEMBL10270528 0.78 BCHE (0.45) LATS1BCHEBRD4STK17BSTK17A
SCHEMBL3815684 0.76 STK17B (0.56) BRD4SIRT5MAPTSTK17BSTK17A
SCHEMBL4273250 0.76 LMNA (0.60) LATS1BCHEBRD4MAPTSTK17B
SCHEMBL3410303 0.74 STK17B (0.49) BRD4SIRT5STK17BSTK17A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1615925-B1 IMIDAZOPYRIDINE DERIVATIVES AS MELANOCORTIN RECEPTOR AGONISTS IPSEN PHARMA (FR) 2009-05-27 — — EP disclosed
US-7495009-B2 Imidazopyridine derivatives as melancortin receptor agonists SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 2009-02-24 — — US disclosed
US-20060173036-A1 Imidazopyridine derivatives as melanocortin receptor agonists SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S) (FR) 2006-08-03 — — US disclosed
EP-1615925-A1 IMIDAZOPYRIDINE DERIVATIVES AS MELANOCORTIN RECEPTOR AGONISTS Société de Conseils de Recherches et d'Applications Scientifiques ( S.C.R.A.S.) (FR) 2006-01-18 — — EP disclosed
WO-2004089951-A1 IMIDAZOPYRIDINE DERIVATIVES HAVING AN AFFINITY FOR MELANOCORTIN RECEPTORS SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 2004-10-21 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060173036-A1 Imidazopyridine derivatives as melanocortin receptor agonists MC4R, MC1R, MC3R LATS1 3321/4885BCHE 4411/4885BRD4 256/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.