Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.31 |
| ▸ | SCD | O00767 | 1/20 | 0.30 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4893403 | 0.78 | CASP3 (0.34) | GRM5MAPTNPC1HDAC1SCD | |
| SCHEMBL811754 | 0.72 | GRM5 (0.47) | GRM5MAPTNPC1RXFP1 | |
| SCHEMBL1415990 | 0.70 | HSD17B1 (0.36) | MAPTNPC1 | |
| SCHEMBL3607890 | 0.68 | HSP90AA1 (0.39) | GRM5 | |
| SCHEMBL7427844 | 0.68 | KDM4E (0.48) | MAPTNPC1RXFP1 | |
| SCHEMBL3835184 | 0.67 | NPC1 (0.44) | GRM5NPC1RXFP1 | |
| SCHEMBL21551796 | 0.67 | KDM4E (0.34) | MAPT | |
| SCHEMBL9077074 | 0.67 | — | — | |
| SCHEMBL533422 | 0.65 | KDM4A (0.38) | NPC1 | |
| SCHEMBL23348866 | 0.65 | GRM5 (0.44) | GRM5MAPTNPC1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091937-A2 | SUBSTITUTED IMIDAZOLES AS BOMBESIN RECEPTOR SUBTYPE-3 MODULATORS | Merck & Co., Inc. (US) | 2009-08-26 | — | — | EP | disclosed |
| WO-2008051406-A2 | SUBSTITUTED IMIDAZOLES AS BOMBESIN RECEPTOR SUBTYPE-3 MODULATORS | MERCK & CO., INC. (US) | 2008-05-02 | — | — | WO | disclosed |