SCHEMBL381634

SCHEMBL381634

Br[Mg]c1ccc(Oc2ccccc2)cc1

nearest known ligand 0.57

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 7/20 0.57
TSHR P16473 1/20 0.57
MAOA P21397 2/20 0.50
NR1H2 P55055 1/20 0.50
BAX Q07812 1/20 0.50
CA1 P00915 2/20 0.45
CA2 P00918 2/20 0.45
GSTP1 P09211 1/20 0.42
SOS1 Q07889 1/20 0.42
CA9 Q16790 1/20 0.42
PARP10 Q53GL7 1/20 0.42
PLA2G2A P14555 1/20 0.42
MAOB P27338 1/20 0.41
MEN1 O00255 1/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
KMT2A Q03164 1/20 0.41
NLRP3 Q96P20 1/20 0.41
SRD5A2 P31213 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7265757 0.80 LTA4H (0.50) LTA4HTSHRMAOANR1H2BAX
SCHEMBL22129853 0.79 LTA4H (0.92) LTA4HTSHRMAOANR1H2BAX
SCHEMBL11576945 0.79 LTA4H (0.92) LTA4HTSHRMAOANR1H2BAX
SCHEMBL435149 0.79 LTA4H (0.92) LTA4HTSHRMAOANR1H2BAX
SCHEMBL9212518 0.79 LTA4H (0.92) LTA4HTSHRMAOANR1H2BAX
SCHEMBL122719 0.79 LTA4H (0.92) LTA4HTSHRMAOANR1H2BAX
SCHEMBL3893562 0.79 LTA4H (0.92) LTA4HTSHRMAOANR1H2BAX
SCHEMBL28454211 0.76 LTA4H (0.57) LTA4HTSHRMAOANR1H2BAX
SCHEMBL28589935 0.76 LTA4H (0.57) LTA4HTSHRMAOANR1H2BAX
SCHEMBL5450 0.76

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 108 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025242747-A1 MULTI -COMPONENT FORMULATIONS OF ORGANOMETALLIC REAGENTS MERCK PATENT GMBH (DE) 2025-11-27 WO claimed
CN-113620869-B Preparation method of betrixaban 江西同和药业股份有限公司 2023-04-18 CN claimed
CN-113620869-A Preparation method of betrixaban 江西同和药业股份有限公司 2021-11-09 CN claimed
US-7273948-B2 Process of preparing esters and ethers of probucol and derivatives thereof ATHEROGENICS, INC. (US) 2007-09-25 US claimed
EP-1594824-A4 PROCESS OF PREPARING ESTERS AND ETHERS OF PROBUCOL AND DERIVATIVES THEREOF ATHEROGENICS INC (US) 2007-04-04 EP claimed
EP-1594824-A2 PROCESS OF PREPARING ESTERS AND ETHERS OF PROBUCOL AND DERIVATIVES THEREOF Atherogenics, Inc. (US) 2005-11-16 EP claimed
US-20040204485-A1 Process of preparing esters and ethers of probucol and derivatives thereof CRABTREE ACQUISITION CO, LLC 2004-10-14 US claimed
WO-2004062622-A2 PROCESS OF PREPARING ESTERS AND ETHERS OF PROBUCOL AND DERIVATIVES THEREOF ATHEROGENICS, INC. (US) 2004-07-29 WO claimed
WO-2025242747-A1 MULTI -COMPONENT FORMULATIONS OF ORGANOMETALLIC REAGENTS MERCK PATENT GMBH (DE) 2025-11-27 WO disclosed
CN-118791384-A Synthesis process of famoxadone intermediate 2- (4-phenoxyphenyl) ethyl lactate 安徽广信农化股份有限公司 2024-10-18 CN disclosed
CN-116730939-A Preparation method of famoxadone characteristic impurities 如东众意化工有限公司 2023-09-12 CN disclosed
CN-113620869-B Preparation method of betrixaban 江西同和药业股份有限公司 2023-04-18 CN disclosed
WO-2023057548-A1 CCR6 RECEPTOR MODULATORS IDORSIA PHARMACEUTICALS LTD (CH) 2023-04-13 WO disclosed
CN-113024565-B Radioactive isotope carbon-14 labeled ibrutinib and synthesis method thereof 上海启甄环境科技有限公司 2022-09-13 CN disclosed
US-4301164-A FOR USE AS ANTIULCER AGENTS, HYPOTENSIVE AGENTS, ANTITHROMBOSIC AGENTS TORAY INDUSTRIES, INC. (JP) 1981-11-17 US disclosed
EP-0024943-A1 5,6,7-Trinor-4,8-inter-m-phenylene PGI2 derivatives and pharmaceutical compositions containing them TORAY INDUSTRIES, INC. (JP) 1981-03-11 EP disclosed
US-4136200-A PHENYLBUTANOL DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1979-01-23 US disclosed
US-4049823-A Phenylbutanol derivatives and compositions containing them MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) 1977-09-20 US disclosed
US-3980795-A Pyrazolidinones and a process for their preparation MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) 1976-09-14 US disclosed
US-3966801-A ANTIINFLAMMATORY AGENTS WILLIAM H. RORER, INC. (US) 1976-06-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040204485-A1 Process of preparing esters and ethers of probucol and derivatives thereof NR3C2, MGLL, GCG LTA4H 2624/4885TSHR 1000/4885MAOA 3685/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.