Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.43 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.42 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL18189763 | 1.00 | HSPD1 (0.55) | HSPD1BLMHSPE1ALDH1A1GPR84 | |
| Citric Acid SCHEMBL30150820 | 1.00 | HSPD1 (0.55) | HSPD1BLMHSPE1ALDH1A1GPR84 | |
| Citric Acid SCHEMBL29563289 | 1.00 | HSPD1 (0.55) | HSPD1BLMHSPE1ALDH1A1GPR84 | |
| Citric Acid SCHEMBL10793339 | 0.98 | ALDH1A1 (0.54) | HSPD1BLMHSPE1ALDH1A1GPR84 | |
| Sebacic Acid SCHEMBL30957100 | 0.94 | FFAR4 (0.58) | HSPD1BLMHSPE1ALDH1A1GPR84 | |
| Citric Acid SCHEMBL29694430 | 0.93 | ALDH1A1 (0.56) | HSPD1BLMHSPE1ALDH1A1GPR84 | |
| Citric Acid SCHEMBL28589360 | 0.90 | FFAR1 (0.61) | HSPD1BLMHSPE1ALDH1A1GPR84 | |
| Citric Acid SCHEMBL27514700 | 0.90 | FFAR1 (0.61) | HSPD1BLMHSPE1ALDH1A1GPR84 | |
| Citric Acid SCHEMBL875432 | 0.87 | ALDH1A1 (0.68) | HSPD1BLMHSPE1ALDH1A1GPR84 | |
| Citric Acid SCHEMBL27642067 | 0.87 | ALDH1A1 (0.68) | HSPD1BLMHSPE1ALDH1A1GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117224730-A | Photo-curing bioactive poly (citrate) -based polyurethane medical adhesive and preparation method thereof | 武汉理工大学 | 2023-12-15 | — | — | CN | claimed |
| CN-117004197-A | Weather-resistant glass fiber reinforced polyglycolic acid composite material and preparation method and application thereof | 中国石油化工股份有限公司 | 2023-11-07 | — | — | CN | claimed |
| CN-110225714-B | Bioabsorbable deformable anchor | 阿库蒂夫科技有限公司 | 2023-01-03 | — | — | CN | claimed |
| EP-3843644-A1 | TENDON INTERFERENCE ANCHOR | Acuitive Technologies, Inc. (US) | 2021-07-07 | — | — | EP | claimed |
| WO-2020046912-A1 | TENDON INTERFERENCE ANCHOR | ACUITIVE TECHNOLOGIES, INC. (US) | 2020-03-05 | — | — | WO | claimed |
| CN-122080895-A | Polyglycolic acid composition and preparation method thereof, biodegradable polyester material and application thereof, and PGA temporary plugging ball and preparation method thereof | — | 2026-05-26 | — | — | CN | disclosed |
| CN-122011402-A | PGA resin edge grafting modified graphene, composition, preparation method and application thereof, biodegradable polyester material, application thereof and temporary plugging ball | 中国石油化工股份有限公司 | 2026-05-12 | — | — | CN | disclosed |
| CN-120859503-B | Degradable fiber electrode fabric for three-dimensional electrogastrogram monitoring and preparation method thereof | 中南大学湘雅医院 | 2026-02-03 | — | — | CN | disclosed |
| CN-120859503-A | Degradable fiber electrode fabric for three-dimensional electrogastrogram monitoring and preparation method thereof | 中南大学湘雅医院 | 2025-10-31 | — | — | CN | disclosed |
| CN-119656381-B | Active organic-inorganic composite implant material and preparation method and application thereof | 广东粤港澳大湾区黄埔材料研究院 | 2025-06-13 | — | — | CN | disclosed |
| CN-119818725-A | Polycitrate composite porous bone scaffold and preparation method thereof | 昆明市中医医院 | 2025-04-15 | — | — | CN | disclosed |
| CN-119656381-A | Active organic-inorganic composite implant material and preparation method and application thereof | 广东粤港澳大湾区黄埔材料研究院 | 2025-03-21 | — | — | CN | disclosed |
| CN-114072495-A | Modified immune cells with enhanced antitumor activity and immunosuppressive resistance | 比姆医疗股份有限公司 | 2022-02-18 | — | — | CN | disclosed |
| CN-111212864-A | Ionomer or oligomer compositions | 宾夕法尼亚州研究基金会 | 2020-05-29 | — | — | CN | disclosed |
| EP-2092455-B1 | ENGINEERED SCAFFOLDS FOR INTERVERTEBRAL DISC REPAIR AND REGENERATION | UNIV MICHIGAN (US) | 2015-05-13 | — | — | EP | disclosed |
| US-20120330423-A1 | Engineered Scaffolds for Intervertebral Disc Repair and Regeneration and for Articulating Joint Repair and Regeneration | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-12-27 | — | — | US | disclosed |
| US-8275594-B2 | Engineered scaffolds for intervertebral disc repair and regeneration and for articulating joint repair and regeneration | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-09-25 | — | — | US | disclosed |
| EP-2092455-A2 | ENGINEERED SCAFFOLDS FOR INTERVERTEBRAL DISC REPAIR AND REGENERATION AND FOR ARTICULATING JOINT REPAIR AND REGENERATION | The Regents Of The University Of Michigan (US) | 2009-08-26 | — | — | EP | disclosed |
| US-20080195211-A1 | Engineered Scaffolds for Intervertebral Disc Repair and Regeneration and for Articulating Joint Repair and Regeneration | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2008-08-14 | — | — | US | disclosed |
| WO-2008082766-A2 | ENGINEERED SCAFFOLDS FOR INTERVERTEBRAL DISC REPAIR AND REGENERATION AND FOR ARTICULATING JOINT REPAIR AND REGENERATION | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-07-10 | — | — | WO | disclosed |