Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.43 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.42 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL18189763 | 1.00 | HSPD1 (0.55) | HSPD1BLMHSPE1ALDH1A1GPR84 | |
| Citric Acid SCHEMBL29563289 | 1.00 | HSPD1 (0.55) | HSPD1BLMHSPE1ALDH1A1GPR84 | |
| Citric Acid SCHEMBL3816409 | 1.00 | HSPD1 (0.55) | HSPD1BLMHSPE1ALDH1A1GPR84 | |
| Citric Acid SCHEMBL10793339 | 0.98 | ALDH1A1 (0.54) | HSPD1BLMHSPE1ALDH1A1GPR84 | |
| Sebacic Acid SCHEMBL30957100 | 0.94 | FFAR4 (0.58) | HSPD1BLMHSPE1ALDH1A1GPR84 | |
| Citric Acid SCHEMBL29694430 | 0.93 | ALDH1A1 (0.56) | HSPD1BLMHSPE1ALDH1A1GPR84 | |
| Citric Acid SCHEMBL28589360 | 0.90 | FFAR1 (0.61) | HSPD1BLMHSPE1ALDH1A1GPR84 | |
| Citric Acid SCHEMBL27514700 | 0.90 | FFAR1 (0.61) | HSPD1BLMHSPE1ALDH1A1GPR84 | |
| Citric Acid SCHEMBL875432 | 0.87 | ALDH1A1 (0.68) | HSPD1BLMHSPE1ALDH1A1GPR84 | |
| Citric Acid SCHEMBL27642067 | 0.87 | ALDH1A1 (0.68) | HSPD1BLMHSPE1ALDH1A1GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260026953-A1 | BALLOON DELIVERY SYSTEM FOR THE IMPLANT DEPLOYMENT | UNIV NORTHWESTERN (US) | 2026-01-29 | — | — | US | disclosed |
| WO-2024020566-A2 | BALLOON DELIVERY SYSTEM FOR THE IMPLANT DEPLOYMENT | NORTHWESTERN UNIVERSITY (US) | 2024-01-25 | — | — | WO | disclosed |
| US-20240009357-A1 | 3D PRINTING OF BIOMEDICAL IMPLANTS | NORTHWESTERN UNIVERSITY | 2024-01-11 | — | — | US | disclosed |
| US-11565026-B2 | 3D printing of biomedical implants | NORTHWESTERN UNIVERSITY (US) | 2023-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260026953-A1 | BALLOON DELIVERY SYSTEM FOR THE IMPLANT DEPLOYMENT | SBDS, SMC3, BAG3 | MEN1 4770/4885HSPD1 2596/4885BLM 3145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.