Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.32 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.32 |
| ▸ | ITGAL | P20701 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | QRFPR | Q96P65 | 1/20 | 0.31 |
| ▸ | PRLHR | P49683 | 2/20 | 0.31 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.31 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 2/20 | 0.30 |
| ▸ | SPR | P35270 | 3/20 | 0.30 |
| ▸ | GRM5 | P41594 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3821039 | 0.90 | GRM5 (0.32) | MAPK1PARP1GRM5 | |
| SCHEMBL3819163 | 0.87 | MAPK1 (0.33) | MAPK1NPSR1MEN1KMT2ADRD1 | |
| SCHEMBL1011176 | 0.86 | GRM5 (0.42) | MAPK1NPSR1QRFPRGRM5 | |
| SCHEMBL3820067 | 0.81 | DRD1 (0.42) | MAPK1NPSR1DRD1TRPC3TRPC6 | |
| SCHEMBL3816607 | 0.81 | KMT2A (0.42) | MAPK1MEN1KMT2ADRD1PARP1 | |
| SCHEMBL3815643 | 0.81 | MAPT (0.38) | MAPK1NPSR1DRD1TRPC3TRPC6 | |
| SCHEMBL3813529 | 0.81 | F11 (0.40) | MAPK1NPSR1MEN1KMT2ADRD1 | |
| SCHEMBL3819764 | 0.80 | MAPK1 (0.34) | MAPK1NPSR1MGLLGRM5 | |
| SCHEMBL3816988 | 0.80 | F11 (0.39) | MAPK1NPSR1DRD1PARP1GRM5 | |
| SCHEMBL1011577 | 0.79 | GRM5 (0.47) | KMT2AGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | claimed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |