Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.63 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.57 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.56 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.56 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.56 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.55 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.55 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.55 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.55 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.55 |
| ▸ | BACE1 | P56817 | 1/20 | 0.55 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4504526 | 0.87 | NPC1 (0.65) | P4HTMSLC6A3KCNH2TAAR1PTPN1 | |
| SCHEMBL180882 | 0.85 | SLC6A3 (0.54) | P4HTMSLC6A3KCNH2TAAR1PTPN1 | |
| SCHEMBL5218095 | 0.82 | KCNQ3 (0.71) | KCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL13989050 | 0.79 | TRPV1 (0.69) | KCNQ3KCNQ2KCNE1KCNQ1TRPV1 | |
| SCHEMBL18048931 | 0.79 | LMNA (0.64) | CYP3A4CYP2C9CYP2C19KMT2A | |
| SCHEMBL3227445 | 0.79 | P4HTM (0.67) | P4HTMPTPN1PTPN6PTPN11CXCR2 | |
| SCHEMBL2801974 | 0.79 | KCNQ3 (0.85) | P4HTMKCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL3064046 | 0.79 | P4HTM (0.67) | P4HTMPTPN1PTPN6PTPN11CXCR2 | |
| SCHEMBL4740817 | 0.79 | KCNQ3 (0.68) | P4HTMPTPN1PTPN6PTPN11CXCR2 | |
| SCHEMBL2801061 | 0.79 | P4HTM (0.67) | P4HTMPTPN1PTPN6PTPN11CXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091917-A1 | ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2009-08-26 | — | — | EP | claimed |
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |
| WO-2008073934-A1 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |