Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | ADK | P55263 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.30 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3820421 | 0.94 | LMNA (0.49) | LMNAADKALDH1A1HPGDRAB9A | |
| SCHEMBL3818930 | 0.91 | LMNA (0.44) | LMNAADKALDH1A1THRBSMN1; SMN2 | |
| SCHEMBL12029798 | 0.87 | LMNA (0.75) | LMNAADKALDH1A1HPGDRAB9A | |
| SCHEMBL12302023 | 0.87 | LMNA (0.75) | LMNAADKALDH1A1HPGDRAB9A | |
| SCHEMBL3821461 | 0.87 | LMNA (0.59) | LMNAADKALDH1A1HPGDRAB9A | |
| SCHEMBL8196421 | 0.87 | LMNA (0.75) | LMNAADKALDH1A1HPGDRAB9A | |
| SCHEMBL12302015 | 0.87 | LMNA (0.75) | LMNAADKALDH1A1HPGDRAB9A | |
| SCHEMBL12945763 | 0.87 | LMNA (0.75) | LMNAADKALDH1A1HPGDRAB9A | |
| SCHEMBL13340646 | 0.87 | LMNA (0.75) | LMNAADKALDH1A1HPGDRAB9A | |
| SCHEMBL285059 | 0.87 | LMNA (0.75) | LMNAADKALDH1A1HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882734-B1 | 5'-Deoxy-cytidine derivatives | HOFFMANN LA ROCHE (CH) | 2009-08-26 | — | — | EP | claimed |
| EP-0882734-A2 | 5'-Deoxy-cytidine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1998-12-09 | — | — | EP | claimed |
| EP-0882734-B1 | 5'-Deoxy-cytidine derivatives | HOFFMANN LA ROCHE (CH) | 2009-08-26 | — | — | EP | disclosed |
| US-6211166-B1 | COADMINISTERED WITH A 5-FLUOROURACIL DERIVATIVE; ANTICARCINOGENIC AGENTS | HOFFMAN-LA ROCHE INC. | 2001-04-03 | — | — | US | disclosed |
| EP-0882734-A2 | 5'-Deoxy-cytidine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1998-12-09 | — | — | EP | disclosed |