Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY1R | P25929 | 16/20 | 0.51 |
| ▸ | NPY5R | Q15761 | 6/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | NPFFR1 | Q9GZQ6 | 2/20 | 0.42 |
| ▸ | NPFFR2 | Q9Y5X5 | 2/20 | 0.42 |
| ▸ | NPY4R | P50391 | 4/20 | 0.42 |
| ▸ | NPY2R | P49146 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1593464 | 0.85 | NPY1R (0.70) | NPY1RNPY5RNPFFR1NPFFR2NPY4R | |
| SCHEMBL28032820 | 0.85 | NPY1R (0.70) | NPY1RNPY5RNPFFR1NPFFR2NPY4R | |
| SCHEMBL7596174 | 0.84 | NPY4R (0.46) | NPY1RNPY5RNPY4RNPY2R | |
| SCHEMBL7596179 | 0.84 | NPY4R (0.46) | NPY1RNPY5RNPY4RNPY2R | |
| SCHEMBL8612664 | 0.83 | CNR1 (0.44) | NPY1RNPY5RCNR1CNR2 | |
| SCHEMBL5057899 | 0.83 | NPY1R (0.53) | NPY1RNPY5RNPFFR1NPFFR2NPY4R | |
| SCHEMBL28745902 | 0.83 | NPY4R (0.51) | NPY1RNPY5RNPY4RNPY2R | |
| SCHEMBL4652031 | 0.82 | NPY1R (0.48) | NPY1RNPY5RCNR1CNR2NPFFR1 | |
| SCHEMBL8068044 | 0.81 | CNR1 (0.41) | NPY1RNPY5RCNR1CNR2NPY4R | |
| SCHEMBL1388761 | 0.80 | NPY1R (0.51) | NPY1RNPY5RNPFFR1NPFFR2NPY4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2089383-A1 | 3-HYDR0XY-1,5-DIHYDR0-PYRR0L-2-ONE DERIVATIVES AS INHIBITORS OF GLUTAMINYL CYCLASE FOR THE TREATMENT OF ULCER, CANCER AND OTHER DISEASES | Probiodrug AG (DE) | 2009-08-19 | — | — | EP | disclosed |
| WO-2008055945-A1 | 3-HYDR0XY-1,5-DIHYDR0-PYRR0L-2-ONE DERIVATIVES AS INHIBITORS OF GLUTAMINYL CYCLASE FOR THE TREATMENT OF ULCER, CANCER AND OTHER DISEASES | PROBIODRUG AG (DE) | 2008-05-15 | — | — | WO | disclosed |