Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 3/20 | 0.77 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | RNASEH1 | O60930 | 3/20 | 0.42 |
| ▸ | CDC7 | O00311 | 2/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.41 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38005 | 0.89 | PDE5A (0.69) | PDE5AKMT2ARNASEH1CDC7CCNE1 | |
| SCHEMBL37513 | 0.88 | PDE5A (0.79) | PDE5AKMT2ARNASEH1CDC7CCNE1 | |
| SCHEMBL37583 | 0.88 | PDE5A (0.78) | PDE5AKMT2ARNASEH1CDC7CCNE1 | |
| SCHEMBL38065 | 0.87 | PDE5A (0.77) | PDE5AHCAR2KMT2ARNASEH1CDC7 | |
| SCHEMBL37798 | 0.87 | PDE5A (1.00) | PDE5AHCAR2KMT2ARNASEH1CDC7 | |
| SCHEMBL37797 | 0.84 | PDE5A (0.72) | PDE5AKMT2ACDC7CCNE1CDK2 | |
| SCHEMBL3495170 | 0.82 | PDE5A (0.77) | PDE5AHCAR2KMT2ARNASEH1MAOB | |
| SCHEMBL37942 | 0.81 | PDE5A (0.78) | PDE5AKMT2ARNASEH1KDM4ELMNA | |
| SCHEMBL44227 | 0.81 | PDE5A (0.67) | PDE5AKMT2ARNASEH1CDC7CCNE1 | |
| SCHEMBL37981 | 0.80 | PDE5A (0.66) | PDE5AKMT2ARNASEH1CDC7CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012004900-A1 | THIENOPYRIMIDINE COMPOUNDS | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2012-01-12 | — | — | WO | disclosed |