SCHEMBL3819616

SCHEMBL3819616

Nc1nccc(CC(c2cccnc2)(c2cccnc2)c2ccc(Cl)c(Cl)c2)n1

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KMO O15229 1/20 0.39
CYP19A1 P11511 6/20 0.37
HSP90AA1 P07900 1/20 0.37
HSP90AB1 P08238 1/20 0.37
PTK2 Q05397 1/20 0.37
KIF11 P52732 3/20 0.37
DYRK1A Q13627 1/20 0.35
CLK4 Q9HAZ1 1/20 0.35
GRM4 Q14833 1/20 0.34
KCNA5 P22460 1/20 0.34
DHFR P00374 1/20 0.33
CYP3A4 P08684 2/20 0.33
ADORA2A P29274 1/20 0.33
CYP2D6 P10635 1/20 0.33
SLC6A2 P23975 1/20 0.33
SLC6A4 P31645 1/20 0.33
SLC6A3 Q01959 1/20 0.33
ADORA1 P30542 1/20 0.33
CYP3A5 P20815 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1377766 0.87 CYP19A1 (0.49) CYP19A1HSP90AA1HSP90AB1PTK2GRM4
SCHEMBL3819185 0.82 CYP19A1 (0.40) CYP19A1HSP90AA1HSP90AB1PTK2KIF11
SCHEMBL1380492 0.79 KIF11 (0.35) CYP19A1KIF11CYP3A4ADORA2ACYP2D6
SCHEMBL1378489 0.78 NUDT1 (0.36) CYP19A1HSP90AA1HSP90AB1PTK2DYRK1A
SCHEMBL1381592 0.77 CYP19A1 (0.41) CYP19A1HSP90AA1HSP90AB1PTK2GRM4
SCHEMBL1380777 0.73 HSP90AA1 (0.36) CYP19A1HSP90AA1HSP90AB1PTK2GRM4
SCHEMBL1379821 0.72 NUDT1 (0.35) CYP19A1HSP90AA1HSP90AB1PTK2DYRK1A
SCHEMBL1377180 0.68 CYP19A1 (0.43) CYP19A1KIF11CYP3A4CYP3A5
SCHEMBL1378463 0.68 CYP19A1 (0.48) CYP19A1KIF11KCNA5
SCHEMBL6000406 0.67 CYP19A1 (0.53) CYP19A1KIF11CYP3A4CYP3A5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1776355-A4 POTASSIUM CHANNEL INHIBITORS MERCK & CO INC (US) 2009-08-12 EP disclosed
EP-1776355-A2 POTASSIUM CHANNEL INHIBITORS Merck & Co., Inc. (US) 2007-04-25 EP disclosed
WO-2006014877-A2 POTASSIUM CHANNEL INHIBITORS MERCK & CO., INC. (US) 2006-02-09 WO disclosed