Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 1/20 | 0.34 |
| ▸ | GPR88 | Q9GZN0 | 2/20 | 0.34 |
| ▸ | BCHE | P06276 | 3/20 | 0.31 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.31 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.30 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3816250 | 1.00 | CAPN1 (0.34) | CAPN1GPR88BCHEGRM1HCRTR1 | |
| SCHEMBL8187785 | 0.91 | GRM1 (0.33) | CAPN1GPR88BCHEGRM1HCRTR1 | |
| SCHEMBL3816032 | 0.87 | DPP4 (0.36) | GPR88GRM1DPP4DPP9 | |
| SCHEMBL3818837 | 0.85 | DPP9 (0.32) | GRM1GRIA2GRIN2AGRIN1DPP4 | |
| SCHEMBL3822208 | 0.84 | GRM1 (0.34) | GRM1HCRTR1GRIA2GRIN2AGRIN1 | |
| SCHEMBL8186622 | 0.84 | CAPN1 (0.40) | CAPN1GPR88BCHEGRM1HCRTR1 | |
| SCHEMBL3060078 | 0.84 | GRM1 (0.35) | GRM1GRIA2GRIN2AGRIN1 | |
| SCHEMBL3822019 | 0.83 | GPR88 (0.38) | CAPN1GPR88BCHEGRM1 | |
| SCHEMBL3820120 | 0.83 | CAPN1 (0.33) | CAPN1BCHEHCRTR1GRIA2GRIN2A | |
| SCHEMBL3816257 | 0.83 | CAPN1 (0.33) | CAPN1BCHEHCRTR1GRIA2GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091917-A1 | ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2009-08-26 | — | — | EP | claimed |
| WO-2008073934-A1 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |