Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR88 | Q9GZN0 | 3/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.37 |
| ▸ | BCHE | P06276 | 2/20 | 0.37 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.36 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8186622 | 0.87 | CAPN1 (0.40) | GPR88BCHECAPN1GRM1MAPT | |
| SCHEMBL3824390 | 0.85 | ALDH1A1 (0.46) | GPR88 | |
| SCHEMBL3820116 | 0.83 | CAPN1 (0.34) | GPR88BCHECAPN1GRM1 | |
| SCHEMBL3816250 | 0.83 | CAPN1 (0.34) | GPR88BCHECAPN1GRM1 | |
| SCHEMBL3822022 | 0.82 | PTGDR2 (0.38) | GPR88PTGDR2BCHECAPN1GRM1 | |
| SCHEMBL3059140 | 0.80 | MEN1 (0.45) | PTGDR2GRM1ALOX5PTGS2MAPT | |
| SCHEMBL8193204 | 0.78 | DNM1L (0.38) | MAPT | |
| SCHEMBL3818572 | 0.77 | BCHE (0.35) | PTGDR2BCHEGRM1ALOX5PTGS2 | |
| SCHEMBL3816032 | 0.76 | DPP4 (0.36) | GPR88GRM1 | |
| SCHEMBL8177573 | 0.75 | BCHE (0.32) | GPR88BCHECAPN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091917-A1 | ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2009-08-26 | — | — | EP | claimed |
| WO-2008073934-A1 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |