Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | IKBKB | O14920 | 1/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3825063 | 0.88 | KDM4E (0.67) | SMN1; SMN2KDM4EHPGDNPC1RAB9A | |
| Trifluoroacetic Acid SCHEMBL3827097 | 0.85 | NOTUM (0.54) | SMN1; SMN2KDM4EHPGDNPC1RAB9A | |
| SCHEMBL3825288 | 0.84 | NOTUM (0.49) | SMN1; SMN2KDM4EHPGDNPC1RAB9A | |
| Trifluoroacetic Acid SCHEMBL3825286 | 0.83 | NOTUM (0.55) | SMN1; SMN2KDM4EHPGDNPC1RAB9A | |
| Trifluoroacetic Acid SCHEMBL3827046 | 0.83 | NOTUM (0.55) | NPC1RAB9AKMT2ANOTUMMAPT | |
| Trifluoroacetic Acid SCHEMBL3822942 | 0.82 | NOTUM (0.54) | SMN1; SMN2NPC1RAB9ANOTUMMAPT | |
| Trifluoroacetic Acid SCHEMBL3634061 | 0.80 | KDM4E (0.58) | SMN1; SMN2KDM4EHPGDNPC1RAB9A | |
| Trifluoroacetic Acid SCHEMBL3822807 | 0.77 | KMT2A (0.49) | SMN1; SMN2HPGDNPC1RAB9AKMT2A | |
| SCHEMBL17001624 | 0.76 | KDM4E (0.64) | SMN1; SMN2KDM4EHPGDNPC1RAB9A | |
| Trifluoroacetic Acid SCHEMBL15573592 | 0.75 | LRRK2 (0.59) | SMN1; SMN2KDM4EHPGDNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2096111-A1 | PYRAZOLES AND USE THEREOF AS DRUGS | Japan Tobacco Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| US-20090036450-A1 | PYRAZOLE COMPOUNDS AND USE THEREOF | JAPAN TOBACCO, INC. (JP) | 2009-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036450-A1 | PYRAZOLE COMPOUNDS AND USE THEREOF | PYGL, GYS2, G6PC1 | SMN1; SMN2 4002/4885KDM4E 1955/4885HPGD 675/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.