Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL660274 | 0.79 | GABRA1 (0.52) | GABRA1GABRB2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8791083 | 0.78 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL11278775 | 0.78 | TAAR1 (0.42) | SLC6A2SLC6A4SLC6A3LMNAALDH1A1 | |
| SCHEMBL10867925 | 0.76 | TAAR1 (0.42) | SLC6A2SLC6A4SLC6A3LMNAALDH1A1 | |
| SCHEMBL3812568 | 0.76 | — | — | |
| SCHEMBL3657320 | 0.76 | MMP12 (0.33) | TP53 | |
| SCHEMBL3020825 | 0.76 | GABRA1 (0.37) | GABRA1GABRB2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL15543860 | 0.74 | FOLH1 (0.48) | LMNAHTTALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL4450092 | 0.73 | IDO1 (0.47) | SLC6A2SLC6A4SLC6A3HTTALDH1A1 | |
| SCHEMBL10398717 | 0.73 | ALDH1A1 (0.36) | GABRA1GABRB2SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2089373-A1 | STAT3/5 ACTIVATION INHIBITOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2009-08-19 | — | — | EP | disclosed |
| EP-1957073-A2 | MEDICINAL DRUG | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-08-20 | — | — | EP | disclosed |
| WO-2008044667-A1 | STAT3/5 ACTIVATION INHIBITOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-04-17 | — | — | WO | disclosed |
| WO-2007066784-A2 | DIARYLETHER DERIVATIVES AS ANTITUMOR AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-06-14 | — | — | WO | disclosed |