Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 10/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.32 |
| ▸ | HTR3B | O95264 | 3/20 | 0.32 |
| ▸ | HTR3A | P46098 | 3/20 | 0.32 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.32 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3817863 | 0.93 | CNR2 (0.34) | CNR2ALDH1A1MEN1KMT2AHTT | |
| SCHEMBL3811696 | 0.90 | CNR2 (0.35) | CNR2ALDH1A1MEN1KMT2AHTT | |
| SCHEMBL3812660 | 0.89 | TRPV4 (0.37) | CNR2ALDH1A1MEN1KMT2AHTT | |
| SCHEMBL3816120 | 0.89 | HTR3E (0.34) | CNR2ALDH1A1MEN1KMT2AHTT | |
| SCHEMBL3815509 | 0.88 | CNR2 (0.38) | CNR2TRPV4HTR3EHTR3BHTR3A | |
| SCHEMBL3812492 | 0.86 | TRPV4 (0.35) | CNR2ALDH1A1MEN1KMT2AHTT | |
| SCHEMBL3810279 | 0.84 | TRPV4 (0.38) | CNR2TRPV4HTR3EHTR3BHTR3A | |
| SCHEMBL3816845 | 0.84 | CNR2 (0.38) | CNR2ALDH1A1TRPV4HTR3EHTR3B | |
| SCHEMBL3816564 | 0.83 | CNR2 (0.35) | CNR2ALDH1A1MEN1KMT2AHTT | |
| SCHEMBL3814253 | 0.80 | CNR2 (0.58) | CNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567150-B1 | DERIVATIVES OF INDOLE-3-CARBOXAMIDE, PREPARATION METHOD THEREOF AND APPLICATION OF SAME IN THERAPEUTICS | SANOFI AVENTIS (FR) | 2009-08-12 | — | — | EP | disclosed |
| US-7202268-B2 | Derivatives of indole-3-carboxamide, preparation method thereof and application of same in therapeutics | SANOFI-AVENTIS (FR) | 2007-04-10 | — | — | US | disclosed |
| US-20050288356-A1 | Derivatives of indole-3-carboxamide, preparation method thereof and application of same in therapeutics | SANOFI-AVENTIS (FR) | 2005-12-29 | — | — | US | disclosed |
| EP-1567150-A1 | DERIVATIVES OF INDOLE-3-CARBOXAMIDE, PREPARATION METHOD THEREOF AND APPLICATION OF SAME IN THERAPEUTICS | Sanofi-Aventis (FR) | 2005-08-31 | — | — | EP | disclosed |
| WO-2004050086-A1 | DERIVATIVES OF INDOLE-3-CARBOXAMIDE, PREPARATION METHOD THEREOF AND APPLICATION OF SAME IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2004-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288356-A1 | Derivatives of indole-3-carboxamide, preparation method thereof and application of same in therapeutics | IDO1, IDO2, TDO2 | CNR2 4/4885ALDH1A1 955/4885MEN1 531/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.