Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 13/20 | 0.76 |
| ▸ | ROCK1 | Q13464 | 10/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.76 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.76 |
| ▸ | PRKACA | P17612 | 3/20 | 0.76 |
| ▸ | PRKX | P51817 | 2/20 | 0.76 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.76 |
| ▸ | GSK3A | P49840 | 1/20 | 0.76 |
| ▸ | GSK3B | P49841 | 1/20 | 0.76 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.76 |
| ▸ | AURKA | O14965 | 1/20 | 0.67 |
| ▸ | GRK5 | P34947 | 1/20 | 0.62 |
| ▸ | MMP13 | P45452 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1584297 | 0.87 | ROCK2 (1.00) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL25719243 | 0.84 | ROCK2 (0.93) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL14082124 | 0.82 | ROCK1 (0.68) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL3402865 | 0.81 | MMP13 (0.67) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL14082327 | 0.81 | ROCK1 (0.69) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL14082194 | 0.81 | ROCK1 (0.72) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL14082521 | 0.81 | ROCK2 (0.79) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL5209384 | 0.80 | MMP13 (0.72) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL8348510 | 0.80 | MMP13 (0.57) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL3810618 | 0.79 | ROCK2 (0.75) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713775-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2009-08-12 | — | — | EP | claimed |
| US-20080275062-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2008-11-06 | — | — | US | claimed |
| EP-1713775-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-25 | — | — | EP | claimed |
| WO-2005074643-A2 | BENZAMIDE COMPOUNDS USEFUL AS ROCK INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-08-18 | — | — | WO | claimed |
| EP-1713775-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2009-08-12 | — | — | EP | disclosed |
| US-20080275062-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2008-11-06 | — | — | US | disclosed |
| US-20080275062-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2008-11-06 | — | — | US | disclosed |
| US-20080275062-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2008-11-06 | — | — | US | disclosed |
| EP-1713775-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005074643-A2 | BENZAMIDE COMPOUNDS USEFUL AS ROCK INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080275062-A1 | Chemical Compounds | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CBR1, CBR3 | ROCK2 3638/4885ROCK1 2695/4885CYP3A4 149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.