Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 8/20 | 0.47 |
| ▸ | CTSL | P07711 | 4/20 | 0.47 |
| ▸ | CTSB | P07858 | 3/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 3/20 | 0.43 |
| ▸ | CTSD | P07339 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9531051 | 0.86 | CTSK (0.47) | CTSKCTSLCTSBCTSSKMT2A | |
| SCHEMBL9937144 | 0.79 | SMN1; SMN2 (0.45) | CTSKCTSLCTSBUSP2SMN1; SMN2 | |
| SCHEMBL15732428 | 0.79 | ALDH1A1 (0.45) | SMN1; SMN2ALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL10076126 | 0.78 | CTSK (0.50) | CTSKCTSLCTSBUSP2SMN1; SMN2 | |
| Benzene SCHEMBL9188076 | 0.78 | ALDH1A1 (0.50) | SMN1; SMN2ALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL2691456 | 0.77 | ALDH1A1 (0.44) | SMN1; SMN2ALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL8939923 | 0.77 | ALDH1A1 (0.47) | SMN1; SMN2ALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL31758053 | 0.76 | USP2 (0.45) | CTSKCTSLCTSBUSP2SMN1; SMN2 | |
| SCHEMBL2096750 | 0.75 | CTSK (0.45) | CTSKCTSLCTSBUSP2SMN1; SMN2 | |
| SCHEMBL1503616 | 0.75 | CTSK (0.45) | CTSKCTSLCTSBUSP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091927-A1 | THIAZOLE AND OXAZOLE-SUBSTITUTED ARYLAMIDES | F. Hoffmann-Roche AG (CH) | 2009-08-26 | — | — | EP | disclosed |
| WO-2008055840-A1 | THIAZOLE AND OXAZOLE-SUBSTITUTED ARYLAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-05-15 | — | — | WO | disclosed |